Human cancer regression antigens.
Human cancer regression antigens. Curr Opin Immunol. 2013 Apr;25(2):284-90 Authors: Kvistborg P, van Buuren MM, Schumacher TN Abstract Cytotoxic T-cells can recognize antigens that are presented on the surface of human tumor cells and thereby mediate cancer regression. Importantly, those immune interventions that have thus far proven most successful in the clinic-i.e. checkpoint blockade and tumor-infiltrating lymphocyte (TIL) therapy-enhance T-cell activity without a deliberate focus on specific antigens. Thus, one major question remains unsolved: what is the nature of the antigens that need to be recognized on human cancer to result in tumor control? Here we discuss the repertoire of human tumor antigens by three main parameters. Firstly, the extent to which these antigens are shared by larger patient groups; secondly, the degree of tumor-restrictive expression; and finally, the likelihood of antigen loss the moment selection pressure is applied. Using this framework, we describe those classes of antigens that can be considered preferable targets in both active and passive T-cell based cancer immunotherapy. PMID: 23566921 [PubMed - in process]
This study investigates the distribution of femoral metastases in cancer patients, specifically addressing the incidence of distal femoral metastases. PET/CT examinations routinely extend only to mid-thigh level, precluding detection of distal metastases. We found a total of 208 femoral metastases in 112 patients. 30% had distal femoral metastases in addition to other areas of involvement. 7% of patients with femoral metastases had only distal femur disease. 6 patients had distal pathologic fractures. Exclusion of the distal femur during PET/CT may result in a missed or delayed diagnosis that could contribute to the develo...
Authors: Xu H, Dong L, Bin Z, Yansong H, Shaofeng L, Chang L, Chen C, Changli W Abstract Despite the excellent efficacy and low toxicity of photoresponse therapy, which has attracted considerable attention for use in non-small cell lung cancer (NSCLC) therapy, unsatisfactory cellular permeability, and instability, both in vitro and in vivo have limited further clinical applications of indole cyanine photosensitizers. Here, we explore the supramolecular self-assembly of a 'hyalurosome' that is mediated by calcium phosphate nanonuclei. Through hyaluronate-mediated CD44 targeting, the constructed hyalurosome...
To identify the independent risk factors of concurrent endometrial cancer among women with endometrial hyperplasia and build the clinical prediction model incorporating the clinical and pathological markers.
We aim to present a modified colpocleisis technique for management of a stage 4 POP after a radical cystectomy/ anterior pelvic exenteration. Additionally, we will briefly review urothelial cancer and surgical management as it relates to gynecology.
To determine the adherence to the recommended practices for performing a risk-reducing bilateral salpingo-oophorectomy (RRBSO) as described by the American College of Obstetricians and Gynecologists and Society of Gynecologic Oncology. We sought to determine if adherence differed by type of training i.e., gynecologic oncologists versus benign gynecologists. Additionally, we aimed to determine the incidence of ovarian cancer diagnosed at the time of RRBSO in a large cohort of patients with a BRCA mutation.
The increasing number of cancer patients and prolonged periods of illness have led to an increase in nurses' stress and various other problems. This research aimed to identify the stress resulting from caring for cancer patients and the methods for coping with stress among cancer care nurses. The research subjects were 180 clinical nurses caring for cancer patients in a hospital in Korea. Stress caused by excessive workloads, inappropriate compensation, and interpersonal conflicts with physicians was high. There was a difference in stress according to age. Coping strategies differed according to religion, education, occupa...
How do alcohol consumption and smoking interact with familial risk for breast cancer?Breast Cancer Research
A two ‐stage multicomponent parenchymal sparing surgical strategy (anatomical extended on left hepatic vein 2‐nd segment liver resection and R1vascular approach) allows the successful resection of synchronous multiple bilobar CRC metastases. AbstractA two ‐stage multicomponent parenchymal sparing surgical strategy (anatomical extended on left hepatic vein 2‐nd segment liver resection and R1vascular approach) allows the successful resection of synchronous multiple bilobar CRC metastases.
Authors: Ouh YT, Min KJ PMID: 32100490 [PubMed - in process]