Cell-Specific Gene Deletion Reveals the Anti-Thrombotic Function of COX1 and Explains the Vascular COX1/Prostacyclin Paradox.

Conclusions:These data demonstrate for the first time that, in healthy animals, endothelial COX1 provides an essential anti-thrombotic tone, which is masked when COX1 activity is lost in both endothelial cells and platelets. These results help us define a new two-component paradigm wherein thrombotic tone is regulated by both COX1 and COX2 through complementary but mechanistically distinct pathways.
PMID: 31510878 [PubMed - as supplied by publisher]

Source: Circulation Research - September 11, 2019 Category: Cardiology Authors: Mitchell JA, Shala F, Elghazouli Y, Warner TD, Gaston-Massuet C, Crescente M, Armstrong PC, Herschman HR, Kirkby NS Tags: Circ Res Source Type: research