Biocompatibility study of different hyaluronan products for intra-articular treatment of knee osteoarthritis

Intra-articular (IA) injection of hyaluronic acid (HA) (IA-HA) is a well-recognized treatment option for pain associated with symptomatic knee osteoarthritis (OA). IA-HA products differ in their HA content, mo...
Source: BMC Musculoskeletal Disorders - Category: Orthopaedics Authors: Tags: Research article Source Type: research

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Publication date: Available online 16 November 2019Source: Orthopaedics &Traumatology: Surgery &ResearchAuthor(s): Christophe Mathoulin, Mathilde GrasAbstractScapholunate ligament tear is most frequently encountered in the aftermath of trauma in supination and extension of the wrist. It generates chronic instability, leading to osteoarthritis. It may be associated with fracture of the distal epiphysis of the radius or of the scaphoid. These lesions are often difficult to diagnose, especially in early stages. Treatment of chronic scapholunate ligament lesions before onset of osteoarthritis is a challenge for the sur...
Source: Orthopaedics and Traumatology: Surgery and Research - Category: Orthopaedics Source Type: research
ConclusionsAccording to the currently available data, PRP injections are beneficial for pain relief and function improvement in patients with OA. This metaanalysis, however, demonstrated that the efficacy of PRP is related to sample size and gender composition. Thus, more randomised controlled trials of high quality and larger patient size, also including gender aspects, are required to understand this phenomenon.
Source: Journal of Orthopaedic Translation - Category: Orthopaedics Source Type: research
Conclusions: MSC therapies in the treatment of knee OA are safe and have shown promising results but the available studies are limited. At this time, no definitive recommendations can be made regarding which MSC source to use. Allogeneic MSCs offer theoretical advantages over autologous MSCs, especially in ease of use and consistency of product, but there are concerns regarding cell viability and vitality, as well as the body’s response to nonautologous products. Future clinical trials should focus on randomized head-to-head comparisons of MSC sources as well as the use of multiple injections for patients with knee OA.
Source: Techniques in Orthopaedics - Category: Orthopaedics Tags: Symposium Source Type: research
ConclusionPre-operative administration of meloxicam might assist the post-operative pain management and care in KOA patients who underwent TKA.
Source: Irish Journal of Medical Science - Category: General Medicine Source Type: research
Conditions:   Pain Syndrome;   Pain, Chronic;   Knee Osteoarthritis Intervention:   Other: Pressure pain threshold and behavioural data Sponsor:   Acibadem University Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Links between pain and joint degradation are poorly understood. We investigated the role of activation of Toll-like receptors (TLR) by cartilage metabolites in initiating and maintaining the inflammatory loop in OA causing joint destruction.
Source: Osteoarthritis and Cartilage - Category: Rheumatology Authors: Source Type: research
Publication date: Available online 13 November 2019Source: Arthroscopy TechniquesAuthor(s): Julio de Pablos Fernández, Lucas Arbeloa-Gutierrez, Antonio Arenas-MiquelezAbstractThe mainstay for treatment of articular deformity caused by advanced tricompartmental osteoarthritis of the knee is total knee arthroplasty. When this is also associated with an extra-articular deformity, this also must be compensated or corrected. In this scenario, it is essential to achieve an optimal mechanical situation by restoring the anatomical and mechanical limb axes and an adequate soft-tissue balance. These premises are necessary to ...
Source: Arthroscopy Techniques - Category: Surgery Source Type: research
Publication date: November 2019Source: Spine Deformity, Volume 7, Issue 6Author(s): Aaron J. Buckland, Leah Steinmetz, Peter Zhou, Dennis Vasquez-Montes, Matthew Kingery, Nicholas D. Stekas, Ethan W. Ayres, Christopher G. Varlotta, Virginie Lafage, Renaud Lafage, Thomas Errico, Peter G. Passias, Themistocles S. Protopsaltis, Jonathan VigdorchikAbstractStudy DesignRetrospective review from a single institution.ObjectiveTo investigate the effect of hip osteoarthritis (OA) on spinopelvic compensatory mechanisms as a result of reduced hip range of motion (ROM) between sitting and standing.Summary of Background DataHip OA resul...
Source: Spine Deformity - Category: Orthopaedics Source Type: research
ConclusionIntra-meniscal administration of PRP under ultrasound guidance directly into meniscal degenerative lesions is feasible and safe. Further randomized controlled studies are needed to definitely confirm the effectiveness of this procedure.
Source: Diagnostic and Interventional Imaging - Category: Radiology Source Type: research
This study is registered with the Netherlands Trial Registry, number NTR5263.FindingsWe screened patients for enrolment between Dec 3, 2015, and May 31, 2018. Patients completed baseline visits and started treatment between Dec 14, 2015, and July 2, 2018, and the last study visit of the last patient was Oct 4, 2018. Of 149 patients assessed for eligibility, 57 (38%) patients were excluded (predominantly because they did not meet one or several inclusion criteria, most often because of an absence of synovial inflammation or of flare-ups after NSAID washout) and 92 (62%) patients were eligible for inclusion. We randomly assi...
Source: The Lancet - Category: General Medicine Source Type: research
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