Analytical and bioanalytical technologies for characterizing antibody-drug conjugates.

Analytical and bioanalytical technologies for characterizing antibody-drug conjugates.
Curr Opin Chem Biol. 2013 Apr 6;
Authors: Alley SC, Anderson KE
Abstract
Antibody-drug conjugates (ADCs) require multiple assays for analytical and bioanalytical characterization due to their heterogeneous and dynamic nature. These assays can help address questions from the drug-loading distribution following conjugation to exposure-response relationships after dosing in vivo. This review describes new assay technologies that have been developed for physiochemical characterization and determination of pharmacokinetic parameters of ADCs.
PMID: 23570980 [PubMed - as supplied by publisher]

Source: Current Opinion in Chemical Biology - April 6, 2013 Category: Biochemistry Authors: Alley SC, Anderson KE Tags: Curr Opin Chem Biol Source Type: research