Implications of non-uniqueness in phylogenetic deconvolution of bulk DNA samples of tumors.

Conclusions: Awareness of non-uniqueness of solutions to the PPM problem is key to drawing accurate conclusions in downstream analyses based on tumor phylogenies. This work provides the theoretical foundations for non-uniqueness of solutions in tumor phylogeny inference from bulk DNA samples.
PMID: 31497065 [PubMed]

Source: Algorithms for Molecular Biology : AMB - September 11, 2019 Category: Molecular Biology Authors: Qi Y, Pradhan D, El-Kebir M Tags: Algorithms Mol Biol Source Type: research