The effect of pseudoexfoliation syndrome on choroidal thickness in open-angle glaucoma

ABSTRACT Purpose: To investigate the effect of pseudoex foliation syndrome on choroidal thickness as compared with healthy individuals and subjects with primary open-angle glaucoma. Methods: This prospective, randomized study included 30 primary open angle glaucoma patients and 30 pseudoexfoliation glaucoma patients with similar demographic characteristics and 30 eyes of 30 healthy individuals comprised the control group. Regular optic nerve and macular images were obtained using a Cirrus HD spectral domain optical coherence tomography instrument, along with macular choroidal thickness measurements with enhanced depth imaging mode. Results: Age, sex, and axial length values were similar among the three groups (p>0.05). The primary open angle glaucoma and pseudoexfoliation glaucoma groups had comparable levels of glaucomatous damage. The mean subfoveal choroidal thickness values in the primary open angle glaucoma, pseudoexfoliation glaucoma, and control groups were 271.80 ± 19.96 μ m, 241.43 ± 32.47 μ m, and 268.03 ± 24.50 μ m, respectively. The pseudoexfoliation glaucoma group had the lowest choroidal thickness values of the three groups (p values: pseudoexfoliation-control: 0.001; pseudoexfoliation-primary open angle glaucoma:0,05). Os grupos de glaucoma prim ário de ângulo aberto e de glaucoma pseudoexfoliativo tinham níveis comparáveis de lesões glaucomatosas. Os valores médios da espessura subfoveal...
Source: Arquivos Brasileiros de Oftalmologia - Category: Opthalmology Source Type: research

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ConclusionsIn our study cohort, early surgery for PFV achieved functional visual acuity in about one-third of patients. Limbal approach to surgery may result in better visual acuity and anatomic results.
Source: Journal of American Association for Pediatric Ophthalmology and Strabismus - Category: Opthalmology Source Type: research
Conditions:   Glaucoma;   Congenital Cataract Intervention:   Sponsor:   Sun Yat-sen University Recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Authors: Kim JM, Kim KN, Kim WJ, Kim CS Abstract PURPOSE: We investigated changes in the thickness of the peripapillary retinal nerve fiber layer (RNFL) following the onset of an epiretinal membrane (ERM) in glaucoma patients. METHODS: Among regularly monitored glaucoma patients, patients with a newly diagnosed ERM were consecutively enrolled. Before and after the onset of ERM, the RNFL thickness was measured using spectral domain optical coherence tomography, and a visual field examination was performed using a Humphrey field analyzer. Changes in RNFL thickness parameters and global indices of the visual field...
Source: Korean Journal of Ophthalmology : KJO - Category: Opthalmology Tags: Korean J Ophthalmol Source Type: research
Abstract PMID: 31612807 [PubMed - in process]
Source: Current Medicinal Chemistry - Category: Chemistry Authors: Tags: Curr Med Chem Source Type: research
Elevated intraocular pressure (IOP) due to insufficient aqueous humor outflow through the trabecular meshwork and Schlemm's canal (SC) is the most important risk factor for glaucoma, a leading cause of blindness worldwide. We previously reported loss of function mutations in the receptor tyrosine kinase TEK or its ligand ANGPT1 cause primary congenital glaucoma in humans and mice due to failure of SC development. Here, we describe a novel approach to enhance canal formation in these animals by deleting a single allele of the gene encoding the phosphatase PTPRB during development. Compared toTek haploinsufficient mice, whic...
Source: eLife - Category: Biomedical Science Tags: Developmental Biology Human Biology and Medicine Source Type: research
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Source: Japanese Journal of Ophthalmology - Category: Opthalmology Source Type: research
Conditions:   Retinitis Pigmentosa;   Maculopathy, Age Related;   Macular Dystrophy;   Macular Edema;   Retinal Detachment;   Retinal Degeneration;   Glaucoma;   Vascular Inflammation;   Hypertension;   Stroke;   Diabetes;   Corneal Dystrophy;   Keratoconus;   Dry Eye;   Trauma Interventions:   Device: High-resolution retinal imaging through adaptive optics;   Device: High-resolution retinal imaging through holographic systems Sponsor:   Centre Hospitalier National d'Ophtalmologie des ...
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Elevated intraocular pressure (IOP) is a major, and currently the only, modifiable risk factor, that has been shown to reduce the risk of glaucoma onset and progression. Diurnal measurements of IOP, usually during office hours, are commonly used for the assessment of IOP variation and the relative success of medical, laser, or surgical IOP-lowering interventions. Such measurements, however, fail to capture variation in IOP over the day/night cycle, which may be influenced by factors such as body position.
Source: Survey of Ophthalmology - Category: Opthalmology Authors: Tags: Major review Source Type: research
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Source: Expert Opinion on Therapeutic Patents - Category: Drugs & Pharmacology Authors: Source Type: research
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Source: American Journal of Ophthalmology - Category: Opthalmology Authors: Tags: Original Articles Source Type: research
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