Primary cilia in Gastric Gastrointestinal Stromal Tumours (GISTs): an ultrastructural study

In this study, we report for the first time the presence of primary cilia (PCs) in spindle and epithelioid tumour cells, an ultrastructural feature we consider of special interest that has hitherto been ignored in the literature dealing with the ultrastructure of GISTs. We also point out the frequent occurrence of multivesicular bodies (MVBs). The ultrastructural findings described in gastric GISTs in this study appear to be relevant considering the critical roles played by PCs and MVBs recently demonstrated in tumourigenic processes.

Source: Journal of Cellular and Molecular Medicine - May 15, 2013 Category: Molecular Biology Authors: Tomás Castiella, Guillermo Muñoz, María José Luesma, Sonia Santander, Mario Soriano, Concepción Junquera Tags: Original Article Source Type: research