High mortality and poor treatment efficacy of immune checkpoint inhibitors in patients with severe grade checkpoint inhibitor pneumonitis in non ‐small cell lung cancer

ConclusionCIP is a serious complication with a poor prognosis associated with high mortality. The efficacy of ICI is significantly worse in patients with severe grade CIP than in those without severe grade CIP. Whether ICIs should be administered to patients with CIP risk factors, such as an ECOG PS score of ≥2 or pre‐existing ILD, should be carefully assessed.

Source: Thoracic Cancer - September 2, 2019 Category: Cancer & Oncology Authors: Mari Tone, Takehiro Izumo, Nobuyasu Awano, Naoyuki Kuse, Minoru Inomata, Tatsunori Jo, Hanako Yoshimura, Jonsu Minami, Kohei Takada, Shingo Miyamoto, Hideo Kunitoh Tags: ORIGINAL ARTICLE Source Type: research