MicroRNA-124 alleviates the lung injury in mice with septic shock through inhibiting the activation of the MAPK signaling pathway by downregulating MAPK14.

CONCLUSION: These results indicated that miR-124 could alleviate the symptoms of ALI by inhibiting the activation of MAPK signaling pathway via subsequent targeting of MAPK14. Additionally, miR-124 may serve as a useful biomarker to alleviate the severity of septic shock-induced lung injury.
PMID: 31476692 [PubMed - as supplied by publisher]

Source: International Immunopharmacology - August 29, 2019 Category: Allergy & Immunology Authors: Pan W, Wei N, Xu W, Wang G, Gong F, Li N Tags: Int Immunopharmacol Source Type: research