What is the optimal timing of antiviral treatment in pregnant hepatitis B carrier with extremely high viral load?

AbstractWe appreciate the comments from Vyas et al. (1) Although our study demonstrated that prediction of infants' immunoprophylaxis failure (IF) is possible in early pregnancy, whether women with extremely high viral load require earlier antiviral treatment for prevention of IF remains unknown.(2) Two randomized controlled trials showed no cases of IF (0/239) after the use of tenofovir disoproxil fumarate (TDF) in women with baseline HBV DNA>5.3log10IU/ml in the third trimester.

https://onlinelibrary.wiley.com/doi/abs/10.1111/aogs.13721?af=R

Source: Acta Obstetricia et Gynecologica Scandinavica - August 25, 2019 Category: OBGYN Authors: Ka Wang Cheung, Mimi Tin Yan Seto, Ernest Hung Yu Ng Tags: LETTER TO EDITOR Source Type: research