Evolution patterns of paroxysmal nocturnal hemoglobinuria clone and clinical implications in acquired bone marrow failure

The Dameshek's riddle raised by Dr. Dameshek in 1967 focused on a provocative question: what do aplastic anemia (AA), paroxysmal nocturnal hemoglobinuria (PNH) and "hypoplastic" leukemia have in common? [1]. The riddle was based on the following clinical observation: frequent development of PNH in AA patients; the overlap between the symptomatic PNH and AA; the similar high prevalence of both PNH and AA in the Orient. In 1992, Young addressed the issue and restated the riddle relevant to the hematopoietic cell clonality, a single "insult" of PNH clone occurring in AA, PNH, and a pre-leukemic condition of myelodysplastic syndrome (MDS) [2].

Source: Experimental Hematology - August 27, 2019 Category: Hematology Authors: Yu Lian, Jun Shi, Neng Nie, Zhendong Huang, Yingqi Shao, Jing Zhang, Jinbo Huang, Xingxin Li, Meili Ge, Peng Jin, Min Wang, Yizhou Zheng Source Type: research