[Predictive assays for responses of tumors and normal tissues in radiation oncology].

[Predictive assays for responses of tumors and normal tissues in radiation oncology]. Cancer Radiother. 2019 Aug 23;: Authors: Riou O, Bourgier C, Brengues M, Bonnefoi N, Michaud HA, Castan F, Gourgou S, Draghici R, Farcy-Jacquet MP, Bons F, Fenoglietto P, Ozsahin M, Azria D Abstract The impact of curative radiotherapy depends mainly on the total dose delivered homogenously in the target volume. Tumor sensitivity to radiotherapy may be particularly inconstant depending on location, histology, somatic genetic parameters and the capacity of the immune system to infiltrate the tumor. In addition, the dose delivered to the surrounding healthy tissues may reduce the therapeutic ratio of many radiation treatments. In a same population treated in one center with the same technique, it appears that individual radiosensitivity clearly exists, namely in terms of late side effects that are in principle non-reversible. This review details the different radiobiological approaches that have been developed to better predict the tumor response but also the radiation-induced late effects. PMID: 31451357 [PubMed - as supplied by publisher]
Source: Cancer Radiotherapie - Category: Cancer & Oncology Authors: Tags: Cancer Radiother Source Type: research