Generation of an induced pluripotent stem cell line (XHCSUi001-A) from urine cells of a patient with spinocerebellar ataxia type 3

Publication date: Available online 27 August 2019Source: Stem Cell ResearchAuthor(s): Lang He, Wei Ye, Zhao Chen, Chunrong Wang, Huifang Zhao, Shuai Li, Linliu Peng, Xiaobo Han, Tiancheng Zhou, Zhiyuan Li, Beisha Tang, Hong JiangAbstractThe induced pluripotent stem cell (iPSC) line XHCSUi001-A generated from urine cells of a female spinocerebellar ataxia type 3/Machado-Joseph disease (SCA3/MJD) patient by using the integration-free methods. The induced XHCSUi001-A retained the disease-causing ATXN3 mutation, expressed pluripotency markers, exhibited a normal karyotype and retained the ability to differentiate into the three germ layers in-vitro and in-vivo. This newly induced iPSC line could be a potential tool for researching the disease-specific mechanisms and drug screening of SCA3/MJD.
Source: Stem Cell Research - Category: Stem Cells Source Type: research