Cancers, Vol. 11, Pages 1251: Tumor Transcriptome Reveals High Expression of IL-8 in Non-Small Cell Lung Cancer Patients with Low Pectoralis Muscle Area and Reduced Survival
Cancers, Vol. 11, Pages 1251: Tumor Transcriptome Reveals High Expression of IL-8 in Non-Small Cell Lung Cancer Patients with Low Pectoralis Muscle Area and Reduced Survival
Cancers doi: 10.3390/cancers11091251
Authors:
Sarah Santiloni Cury
Diogo de Moraes
Paula Paccielli Freire
Grasieli de Oliveira
Douglas Venâncio Pereira Marques
Geysson Javier Fernandez
Maeli Dal-Pai-Silva
Érica Nishida Hasimoto
Patricia Pintor dos Reis
Silvia Regina Rogatto
Robson Francisco Carvalho
Cachexia is a syndrome characterized by an ongoing loss of skeletal muscle mass associated with poor patient prognosis in non-small cell lung cancer (NSCLC). However, prognostic cachexia biomarkers in NSCLC are unknown. Here, we analyzed computed tomography (CT) images and tumor transcriptome data to identify potentially secreted cachexia biomarkers (PSCB) in NSCLC patients with low-muscularity. We integrated radiomics features (pectoralis muscle, sternum, and tenth thoracic (T10) vertebra) from CT of 89 NSCLC patients, which allowed us to identify an index for screening muscularity. Next, a tumor transcriptomic-based secretome analysis from these patients (discovery set) was evaluated to identify potential cachexia biomarkers in patients with low-muscularity. The prognostic value of these biomarkers for predicting recurrence and survival outcome was confirmed using expression data from eight lung cancer datasets (validation set). Finally, C2C12 myoblasts differentiated into myotu...
Source: Cancers - Category: Cancer & Oncology Authors: Sarah Santiloni Cury Diogo de Moraes Paula Paccielli Freire Grasieli de Oliveira Douglas Ven âncio Pereira Marques Geysson Javier Fernandez Maeli Dal-Pai-Silva Érica Nishida Hasimoto Patricia Pintor dos Reis Silvia Regina Rogatto Robson Francisco Carval Tags: Article Source Type: research
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