New insights into lipopolysaccharide assembly and export.

New insights into lipopolysaccharide assembly and export.
Curr Opin Chem Biol. 2019 Aug 21;53:37-43
Authors: Sweeney RP, Lowary TL
Abstract
Lipopolysaccharide is an important immunomodulatory and structural component found in the outer membrane of Gram-negative bacteria. The biosynthesis of this glycoconjugate proceeds by a highly conserved pathway and, as such, is an attractive target for antibiotic action. We highlight here recent work focused on understanding this pathway with an emphasis on new insights related to chain length control and transport across the inner and outer cell membranes.
PMID: 31445442 [PubMed - as supplied by publisher]

Source: Current Opinion in Chemical Biology - August 20, 2019 Category: Biochemistry Authors: Sweeney RP, Lowary TL Tags: Curr Opin Chem Biol Source Type: research