PHOTOCOAGULATION VERSUS RANIBIZUMAB FOR PROLIFERATIVE DIABETIC RETINOPATHY: Should Baseline Characteristics Affect Choice of Treatment?

Purpose: Among eyes with proliferative diabetic retinopathy, identify whether baseline characteristics impact the benefit of ranibizumab over panretinal photocoagulation (PRP) in DRCR.net Protocol S. Methods: Participants had proliferative diabetic retinopathy, visual acuity of 20/320 or better, and no previous PRP. Eyes were randomized to PRP or intravitreous 0.5-mg ranibizumab. Results: Ranibizumab was superior to PRP for change in visual acuity and development of vision-impairing central-involved diabetic macular edema over 2 years (P
Source: RETINA - Category: Opthalmology Tags: Original Study Source Type: research

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Conclusion Our study provides novel evidence that EXE-induced antisenescence against metabolic distress in the hippocampus may be a key neuroprotective mechanism, preventing neuroinflammation and oxidative stress.
Source: Medicine and Science in Sports and Exercise - Category: Sports Medicine Tags: BASIC SCIENCES Source Type: research
Purpose Low-attenuation muscle (LAM) area at mid-thigh, a computed tomography (CT)–derived index of intramuscular lipids, is associated with insulin resistance, obesity, and type 2 diabetes. The present study aimed at testing the hypothesis that changes in LAM area in trunk muscles from a single abdominal scan could provide relevant information to evaluate the effects of a lifestyle intervention without the use of a mid-thigh CT scan. Methods Cardiometabolic risk variables, including waist circumference, lipoprotein–lipid profile, glucose tolerance, and cardiorespiratory fitness, were assessed in a sample ...
Source: Medicine and Science in Sports and Exercise - Category: Sports Medicine Tags: APPLIED SCIENCES Source Type: research
This study investigated whether periodontal treatment might improve glycemic control in patients with chronic periodontitis and type 2 diabetes mellitus, and which modality offers most benefit.BMC Oral Health
Source: Medscape Today Headlines - Category: Consumer Health News Tags: Dental & Oral Health Journal Article Source Type: news
CONCLUSIONS: LL-37 concentrations were highest in patients with T2DM+CP when compared with controls. LL-37 was positively correlated with age. HNP 1-3 levels were increased in groups with DM when compared to the groups without periodontitis. The role of AMPs is vital in the immunoinflammatory response in the pathogenesis of periodontitis and DM. PMID: 31522161 [PubMed - in process]
Source: Journal of the International Academy of Periodontology - Category: Dentistry Tags: J Int Acad Periodontol Source Type: research
CONCLUSION: Prevalence of severe periodontitis was 10.6%, a lower percentage than other epidemiological studies in Latin America; but still a high proportion of individuals, which would support the importance of preventive and treatment strategies for the country. PMID: 31522152 [PubMed - in process]
Source: Journal of the International Academy of Periodontology - Category: Dentistry Tags: J Int Acad Periodontol Source Type: research
CONCLUSIONS: RC individuals in public or academic PMT programs presented with lower periodontal retreatment needs and progression of periodontitis, as well as tooth loss when compared to IC individuals. PMID: 31522149 [PubMed - in process]
Source: Journal of the International Academy of Periodontology - Category: Dentistry Tags: J Int Acad Periodontol Source Type: research
Two powerhouses in pharma and medtech are working together to help people with diabetes better manage their condition. Abbott Laboratories and Sanofi will collaborate to integrate glucose sensing and insulin delivery technologies. The two companies will take an innovative approach to connected care by developing tools that combine the Abbott Park, Il-based company’s FreeStyle Libre technology with Paris-based Sanofi′s insulin dosing information. Initially, the collaboration enables data sharing, at the consent of the user, between Abbott′s FreeStyle Libre mobile app and...
Source: MDDI - Category: Medical Devices Authors: Tags: IVD Business Source Type: news
Source: BMJ Comments - Category: General Medicine Source Type: forums
Journal Name: Journal of Pediatric Endocrinology and Metabolism Issue: Ahead of print
Source: Journal of Pediatric Endocrinology and Metabolism - Category: Endocrinology Source Type: research
In conclusion, the occurrence of clinically detectable gingival inflammation was lower in heavy smokers than light and moderate smokers. Older age, diabetes, and visible plaque emerged as risk indicators of gingivitis. Plaque and gingival indices are significantly associated regardless of the smoking status.
Source: Brazilian Oral Research - Category: Dentistry Source Type: research
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