Purpose: Among eyes with proliferative diabetic retinopathy, identify whether baseline characteristics impact the benefit of ranibizumab over panretinal photocoagulation (PRP) in Protocol S. Methods: Participants had proliferative diabetic retinopathy, visual acuity of 20/320 or better, and no previous PRP. Eyes were randomized to PRP or intravitreous 0.5-mg ranibizumab. Results: Ranibizumab was superior to PRP for change in visual acuity and development of vision-impairing central-involved diabetic macular edema over 2 years (P
Source: RETINA - Category: Opthalmology Tags: Original Study Source Type: research

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Publication date: 15 November 2020Source: Life Sciences, Volume 261Author(s): Yuan Zhang, Hui Jiang, Shengqian Dou, Bin Zhang, Xia Qi, Jing Li, Qingjun Zhou, Weina Li, Chen Chen, Qun Wang, Lixin Xie
Source: Life Sciences - Category: Biology Source Type: research
Source: Patient Preference and Adherence - Category: International Medicine & Public Health Tags: Patient Preference and Adherence Source Type: research
Discussion Syphilis is caused by the spirochete Treponema pallidum. It is a very old disease that despite understanding the organism and readily available treatment, still causes disease. Syphilis is transmitted sexually. According to the Centers for Disease Control, “[i]n 2018, a total of 35,063 cases of [Primary and Secondary] syphilis were reported in the United States, yielding a rate of 10.8 cases per 100,000 population …. This rate represents a 14.9% increase compared with 2017 (9.4 cases per 100,000 population), and a 71.4% increase compared with 2014 (6.3 cases per 100,000 population).” The incre...
Source: - Category: Pediatrics Authors: Tags: Uncategorized Source Type: news
Quantitative ultrasound (qUS) is an objective, painless, and cost-effective modality that can distinguish healthy from damaged muscle. The cardinal feature of abnormal muscle on qUS is increased echointensity (EI). Increased EI has been demonstrated in humans with DMD and in the mdx mouse model; however, it remains to be determined if the pattern of increased EI is similar in all muscular disorders. We compared qUS images from two disease models that impact muscle in dissimilar ways: the D2-mdx mouse, a model of DMD characterized by increased fibrosis, and the db/db diabetic obese mouse, known to develop muscle atrophy and...
Source: Neuromuscular Disorders - Category: Neurology Authors: Source Type: research
Mutations in the MT-ATP6 are a well-known cause of maternally inherited mitochondrial disorders associated with a wide range of clinical phenotypes. Here, we present a 31-year-old female with type 1 diabetes mellitus, recurrent severe lactic acidosis and ketoacidosis, recurrent infections with suspected immunodeficiency with T cell lymphopenia and hypogammaglobulinaemia, as well as proximal tetraparesis with severe muscle and limb pain and rapid physical exhaustion. Muscle biopsy and respiratory chain activities were normal.
Source: Neuromuscular Disorders - Category: Neurology Authors: Source Type: research
This review summarizes fish protein hydrolysates (FPH) and their effect on blood glucose/obesity. Specific peptides in these FPH are also discussed. The results show that FPH are generally useful for lowering blood glucose and managing appetite. By addressing methodological issues, and if future studies focus on discovering mechanism of action, they could be useful for future nutritional interventions. AbstractPrevalence of type 2 diabetes and overweight/obesity are increasing globally. Food supplementation as a preventative option has become an attractive option in comparison to increased pharmacotherapy dependency. Hydro...
Source: Molecular Nutrition and Food Research - Category: Food Science Authors: Tags: Review Source Type: research
DIABETES type 2 symptoms may include feeling unusually tired, passing more urine than normal, and having cuts or wounds that take longer to heal than expected. But you could also be at risk of high blood sugar if you develop a "relatively common skin condition". These are the diabetes signs you should know about.
Source: Daily Express - Health - Category: Consumer Health News Source Type: news
In conclusion, it remains unclear if brain-specific regional and temporal changes occur in the expression of the different APP variants during AD progression. Since APP is also found in blood cells, assessing the changes in APP mRNA expression in peripheral blood cells from AD patients has been considering an alternative. However, again the quantification of APP mRNA in peripheral blood cells has generated controversial results. Brain APP protein has been analyzed in only a few studies, probably as it is difficult to interpret the complex pattern of APP variants and fragments. We previously characterized the soluabl...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
The objective was to identify the macro- and microangiopathy variables predictive of amputation of the lower extremities (LE) in DT2 patients among.
Source: Annals of Vascular Surgery - Category: Surgery Authors: Source Type: research
Patients presenting type 2 diabetes appear paradoxically protected from the appearance and the evolution of an abdominal aortic aneurysm (AAA). Immune cells take an active part in the weakening of the aortic wall of AAAs, with an important role of the macrophages. Their pro or anti-inflammatory phenotype is partly determined by the cellular metabolism. We hypothesized that diabetes could influence the metabolic phenotype of the macrophages, and thus explain the protective role of diabetes in AAAs.
Source: Annals of Vascular Surgery - Category: Surgery Authors: Source Type: research
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