Cancers, Vol. 11, Pages 1241: The Diverse Contributions of Fucose Linkages in Cancer

Cancers, Vol. 11, Pages 1241: The Diverse Contributions of Fucose Linkages in Cancer Cancers doi: 10.3390/cancers11091241 Authors: Tyler S. Keeley Shengyu Yang Eric Lau Fucosylation is a post-translational modification of glycans, proteins, and lipids that is responsible for many biological processes. Fucose conjugation via α(1,2), α(1,3), α(1,4), α(1,6), and O’- linkages to glycans, and variations in fucosylation linkages, has important implications for cancer biology. This review focuses on the roles that fucosylation plays in cancer, specifically through modulation of cell surface proteins and signaling pathways. How L-fucose and serum fucosylation patterns might be used for future clinical diagnostic, prognostic, and therapeutic approaches will be discussed.
Source: Cancers - Category: Cancer & Oncology Authors: Tags: Review Source Type: research