Viruses, Vol. 11, Pages 781: The Role of Reference Materials in the Research and Development of Diagnostic Tools and Treatments for Haemorrhagic Fever Viruses

We describe reference materials that have been or are being developed for haemorrhagic fever viruses and consider the issues surrounding their production, particularly that of biosafety where the viruses require specialised containment facilities. Finally, we advocate the use of reference materials at early stages, including research and development, as this helps produce reliable assays and can smooth the path to regulatory approval.
Source: Viruses - Category: Virology Authors: Tags: Review Source Type: research

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ConclusionsOur projections are concentrated in a range up to about 300 cases beyond those already reported. While a catastrophic outbreak is not projected, it is not ruled out, and prevention and vigilance are warranted. Prospective validation of our models in real time allowed us to generate more accurate short-term forecasts, and this process may prove useful for future real-time short-term forecasting. We estimate that transmission rates are higher than would be seen under target levels of 62% coverage due to contact tracing and vaccination, and this model estimate may offer a surrogate indicator for the outbreak response challenges.
Source: PLoS Neglected Tropical Diseases - Category: Tropical Medicine Authors: Source Type: research
(KAMPALA, Uganda) — Researchers in Uganda have launched the largest-ever trial of the experimental Ebola vaccine that is expected to be deployed in neighboring Congo, where a deadly outbreak has killed over 1,800 people. The trial of the Janssen Pharmaceuticals vaccine involves up to 800 people in the western district of Mbarara and is supported by Doctors without Borders and the London School of Hygiene and Tropical Medicine. Pontiano Kaleebu, a Ugandan researcher who leads the trial, said Friday that he regrets that the Janssen vaccine has not yet been deployed in Congo. The health minister there who stepped down l...
Source: TIME: Health - Category: Consumer Health News Authors: Tags: Uncategorized congo ebola onetime Uganda vaccine Source Type: news
More than 1,500 deaths and 2,500 people sickened – that’s the recent account of the ebola outbreak in the Democratic Republic of Congo (DRC) raging in the country since last August, and recently declared a public health emergency of international concern. Experts say efforts to contain the virus are hindered by biological, public health, political, and cultural issues, but we looked around what digital health technologies could do to mitigate the spread and the devastation of the infectious disease. The Spaghetti-like virus… The lethal Ebola virus first appeared in 1976 around a river in Congo &nda...
Source: The Medical Futurist - Category: Information Technology Authors: Tags: Future of Medicine Africa AI artificial intelligence Congo digital digital health digital maps disease disease outbreak ebola epidemic Innovation technology Source Type: blogs
Congo's health minister resigned on Monday after being stripped of responsibility for managing the country's Ebola outbreak, potentially paving the way for the introduction of a second vaccine to contain the spreading epidemic.Reuters Health Information
Source: Medscape Medical News Headlines - Category: Consumer Health News Tags: Infectious Diseases News Source Type: news
Congo's health minister resigned on Monday after being stripped of responsibility for managing the country's Ebola outbreak, potentially paving the way for the introduction of a second vaccine to contain the spreading epidemic.
Source: Reuters: Health - Category: Consumer Health News Tags: healthNews Source Type: news
[RFI] Uganda has fast-tracked testing of Ebola vaccines, as the WHO declared the outbreak in neighboring Democratic Republic of Congo a "public health emergency of international concern", a rare designation only used for the gravest epidemics.
Source: AllAfrica News: Health and Medicine - Category: African Health Source Type: news
Hemorrhagic fever inspires almost mythic terror, but whether it can be beaten depends more on people than on medical advances.
Source: NYT Health - Category: Consumer Health News Authors: Tags: Ebola Virus Epidemics Vaccination and Immunization World Health Organization Africa Congo, Democratic Republic of (Congo-Kinshasa) Goma (Congo, Democratic Republic of) Mbandaka (Congo, Democratic Republic of) West Africa Source Type: news
Even with more than 1,400 dead, the W.H.O. says the risk of the disease spreading beyond the region remains low and declaring an emergency could have backfired.
Source: NYT Health - Category: Consumer Health News Authors: Tags: Epidemics Ebola Virus Vaccination and Immunization World Health Organization Centers for Disease Control and Prevention United Nations Children ' s Fund Congo, Democratic Republic of (Congo-Kinshasa) Africa Uganda Tedros Adhanom Gheb Source Type: news
(KASINDI, Congo) — A 5-year-old boy vomiting blood became the first cross-border victim of Ebola in the current outbreak on Wednesday, while two more people in Uganda tested positive for the highly contagious disease that has killed nearly 1,400 in Congo. The boy, part of a Congolese family who crossed into Uganda earlier in the week, died overnight, the World Health Organization said. Ugandan authorities said the two new cases are his 3-year-old brother and 50-year-old grandmother, who have been isolated at a hospital near the border. Uganda now has three confirmed Ebola cases. Authorities tried to determine how the...
Source: TIME: Health - Category: Consumer Health News Authors: Tags: Uncategorized Disease ebola Infectious Disease onetime Uganda Source Type: news
Pregnant women &vaccines against emerging epidemic threats: Ethics guidance for preparedness, research, and response. Vaccine. 2019 May 03;: Authors: Krubiner CB, Faden RR, Karron RA, Little MO, Lyerly AD, Abramson JS, Beigi RH, Cravioto AR, Durbin AP, Gellin BG, Gupta SB, Kaslow DC, Kochhar S, Luna F, Saenz C, Sheffield JS, Tindana PO, PREVENT Working Group Abstract Zika virus, influenza, and Ebola have called attention to the ways in which infectious disease outbreaks can severely - and at times uniquely - affect the health interests of pregnant women and their offspring. These examples also hig...
Source: Vaccine - Category: Allergy & Immunology Authors: Tags: Vaccine Source Type: research
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