Synthesis and antibacterial evaluation of Mannich bases derived from 1,2,4-triazole.

Synthesis and antibacterial evaluation of Mannich bases derived from 1,2,4-triazole.
Chem Biodivers. 2019 Aug 22;:
Authors: Wujec M, Paneth A, Trotsko N, Popiołek Ł, Grzegorczyk A, Krzanowski T, Janowska S, Malm A
Abstract
The series of novel Mannich bases were synthesized and evaluated for their in vitro antibacterial activity against Gram-positive and Gram-negative bacterial strains. The results showed that all compounds were less active than the drugs used as reference, but some of them had moderate potency against Staphylococcus epidermidis ATCC 12228 and Bacillus subtilis ATCC 6633. The presence of a phenyl ring in the position 4 of piperazine seems to be a necessary for antibacterial activity in this class of compounds.
PMID: 31436917 [PubMed - as supplied by publisher]

Source: Chemistry and Biodiversity - August 21, 2019 Category: Biochemistry Authors: Wujec M, Paneth A, Trotsko N, Popiołek Ł, Grzegorczyk A, Krzanowski T, Janowska S, Malm A Tags: Chem Biodivers Source Type: research