Understanding the glucoregulatory mechanisms of metformin in type 2 diabetes mellitus

Nature Reviews Endocrinology, Published online: 22 August 2019; doi:10.1038/s41574-019-0242-2Metformin is the first-line drug for treatment of type 2 diabetes mellitus (T2DM) and is effective in decreasing plasma glucose levels. This review summarizes the glucoregulatory mechanisms of metformin in T2DM and highlights emerging evidence that metformin decreases obesity-induced meta-inflammation and acts in the gastrointestinal tract.
Source: Nature Reviews Endocrinology - Category: Endocrinology Authors: Source Type: research