Gene Studies Could Point to New Alzheimer's Treatments

Title: Gene Studies Could Point to New Alzheimer's TreatmentsCategory: Health NewsCreated: 4/25/2013 12:35:00 PMLast Editorial Review: 4/26/2013 12:00:00 AM
Source: MedicineNet Alzheimer - Category: Geriatrics Source Type: news

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This study investigated the functional brain connectome architecture in patients with Posterior Cortical Atrophy (PCA). Eighteen PCA patients and 29 age- and sex- matched healthy controls were consecutively recruited in a specialized referral center. Participants underwent neurologic examination, cerebrospinal fluid (CSF) examination for Alzheimer's disease (AD) biomarkers, cognitive assessment, and brain MRI. For a smaller subset of participants, FDG-PET examination was available. We assessed topological brain network properties and regional functional connectivity as well as intra- and inter-hemispheric connectivity...
Source: NeuroImage: Clinical - Category: Radiology Source Type: research
CONCLUSIONS: BPMSE has a limited predictive value for the variables studied. PMID: 31739306 [PubMed - as supplied by publisher]
Source: Dementia and Geriatric Cognitive Disorders - Category: Psychiatry Tags: Dement Geriatr Cogn Disord Source Type: research
Funding Opportunity RFA-NS-20-012 from the NIH Guide for Grants and Contracts. This initiative will provide two years of support for planning activities necessary for initiating a Phase III clinical trial designed to validate VCID biomarkers and/or treat patients with VCID. The full spectrum of VCID is in scope, and the one or more VCID disorders(s) to be targeted in the trial must be clearly specified in the application, for example (but not limited to): vascular insults including clinical stroke, silent infarcts and microinfarcts, leukoaraiosis, cerebral amyloid angiopathy (CAA), transient ischemic attack (TIA), micro-b...
Source: NIH Funding Opportunities (Notices, PA, RFA) - Category: Research Source Type: funding
In this study, we illustrated that Pterostilbene (PTS), a kind of resveratrol analog which showed higher scores on BBB and OB, could overcome Aβ-induced neurotoxicity in vitro and in vivo. In silico simulation indicated PTS binding with PDE4A may contribute to its anti-apoptosis and anti-neurotoxicity effects. Behavioral tests further confirmed PTS' potential of overcoming memory deficits in APP/PS1 mice (AD model). Interestingly, PTS also rescued the reducing in dendritic spine density in APP/PS1 mice based on Golgi-Cox staining. Besides, as results of reversing Aβ-induced decreases in cyclic-AMP level, PTS incr...
Source: American Journal of Translational Research - Category: Research Tags: Am J Transl Res Source Type: research
I tried to kill my father for years. To be fair, I was following his wishes. He’d made it clear that when he no longer recognized me, when he could no longer talk, when the nurses started treating him like a toddler, he didn’t want to live any longer. My father was 58 years old when he was diagnosed with Alzheimer’s disease. He took the diagnosis with the self-deprecating humor he’d spent a lifetime cultivating, constantly cracking jokes about how he would one day turn into a zombie, a walking corpse. We had a good 10 years with him after the diagnosis. Eventually, his jokes came true. Seven years ...
Source: TIME: Health - Category: Consumer Health News Authors: Tags: Uncategorized Alzheimer's Disease Source Type: news
DEMENTIA, in particular Alzheimer ’s disease, effects 850,000 people in the UK. This figure is set to rise to two million by 2015. There is currently no cure for dementia, however, a new study has suggested Alzheimer’s disease could be predicted by a brain scan decades before symptoms develop.
Source: Daily Express - Health - Category: Consumer Health News Source Type: news
We present here the development of an electrochemical immunosensor based on nanostructured screen-printed carbon electrodes for the quantification of unfolded p53 in plasma samples. The sensor shows a suitable linear range (from 2 to 50 nM) for its application in real blood samples and a very low limit of detection (0.05 nM). The concentration of unfolded p53 has been accurately detected in plasma of elderly people in healthy conditions, subjects with mild cognitive impairment (MCI) and Alzheimer's Disease (AD) subjects, obtaining results with no significant differences to those provided by an ELISA assay. These result...
Source: Analytica Chimica Acta - Category: Chemistry Authors: Tags: Anal Chim Acta Source Type: research
(DZNE - German Center for Neurodegenerative Diseases) Inflammation drives the progression of neurodegenerative brain diseases and plays a major role in the accumulation of tau proteins within neurons. An international research team led by the German Center for Neurodegenerative Diseases (DZNE) and the University of Bonn comes to this conclusion in the journal Nature. The results indicate that inflammatory processes represent a potential target for future therapies.
Source: EurekAlert! - Medicine and Health - Category: International Medicine & Public Health Source Type: news
Contributors : Faten A Sayed ; Lay Kodama ; Joe C Udeochu ; Hansruedi Mathys ; David Le ; Xiang Niu ; Linas Mazutis ; Lu Zhou ; Xueqiao Jiang ; Tara E Tracy ; Xueting Wang ; Fuying Gao ; Maria Telpoukhovskaia ; Gillian K Carling ; Yueming Li ; Georgia Frost ; Yungui Zhou ; Yaqiao Li ; Zuolin Cheng ; Guoqian Yu ; Qingyun Li ; John Hardy ; Giovanni Coppola ; Li-Huei Tsai ; Li GanSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusThe hemizygous R47H variant of TREM2, a microglia-specific gene in the brain, increases risk for late-onset Alzheimer ’s disease (AD). To understand its path...
Source: GEO: Gene Expression Omnibus - Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Mus musculus Source Type: research
ConclusionsOHRQoL may not fully represent actual oral health problems of patients with AD. Clinical dentists should evaluate oral problems in this population, preferably by using both subjective and objective examinations, including oral and dental conditions. This will ensure oral problems among patients with AD can be detected early and timely treatment provided.
Source: The Journal of Prosthetic Dentistry - Category: Dentistry Source Type: research
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