EP News: Basic and Translational

The steep voltage dependence of gating of the voltage-gated Na channel (NaV) is essential for electrical excitability. However, the structural basis of voltage gating mechanisms remains uncertain because the resting state exists only at deeply negative membrane potentials. In the current study, Wisedchaisri et  al (Cell 2019;DOI:10.1016/j.cell.2019.06.031, PMID 31353218) stabilized the resting conformation by inserting voltage-shifting mutations and introduced a disulfide crosslink in the voltage-sensing module (VS) of the ancestral bacterial Na channel NaVAb.

Source: Heart Rhythm - August 20, 2019 Category: Cardiology Authors: Nipavan Chiamvimonvat Tags: EP News Source Type: research