Role of Sputum Cytology in ACO

Condition:   COPD, Asthma,ACO Intervention:   Biological: sputum cytology Sponsor:   Assiut University Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials

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Contributors : Sandra Ruiz-Garcia ; Marie Deprez ; K Lebrigand ; A Paquet ; A Cavard ; I Caballero ; M J Arguel ; S Leroy ; C H Marquette ; P Barbry ; L E ZaragosiSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiens ; Mus musculus ; Sus scrofaThe upper airway epithelium is mainly composed of 4 cell types: multiciliated, goblet, secretory and basal cells. It constitutes an efficient first line of defense of the respiratory tract against a large panel of inhaled substances. Upon injury, regeneration of this epithelium through proliferation and differentiation events can restore a proper muc...
Source: GEO: Gene Expression Omnibus - Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Homo sapiens Mus musculus Sus scrofa Source Type: research
Publication date: Available online 18 September 2019Source: The Journal of Allergy and Clinical Immunology: In PracticeAuthor(s): Marcia Vervloet, Liset van Dijk, Peter Spreeuwenberg, David Price, Alison Chisholm, Eric Van Ganse, Hilary Pinnock, Cynthia S. Rand, Michelle N. Eakin, Tjard Schermer, Patrick C. Souverein, Alexandra L. Dima, Respiratory Effectiveness Group’s Adherence Working GroupAbstractBackgroundLow inhaled corticosteroids (ICS) adherence is associated with increased asthma burden. This relationship is likely bidirectional, and may vary across adherence stages (initiation, implementation, persistence)....
Source: The Journal of Allergy and Clinical Immunology: In Practice - Category: Allergy & Immunology Source Type: research
Leserbrief zu Hausen T. Die Verordnungen bei Asthma und COPD in Deutschland für die Jahre 2007, 2010, 2013, 2015 – 2017. Pneumologie 2019; 73: 340 – 346. Pneumologie. 2019 Sep;73(9):550-551 Authors: Stollewerk D PMID: 31533178 [PubMed - in process]
Source: Pneumologie - Category: Respiratory Medicine Tags: Pneumologie Source Type: research
Normal spirometry is often used to preclude airway disease in individuals with unspecific respiratory symptoms. We tested the hypothesis that chronic respiratory symptoms are associated with respiratory hospitalisations and death in individuals with normal spirometry without known airway disease. We included 108 246 randomly chosen individuals aged 20–100 years from a Danish population-based cohort study. Normal spirometry was defined as a pre-bronchodilator forced expiratory volume in 1 s/forced vital capacity ratio ≥0.70. Chronic respiratory symptoms included dyspnoea, chronic mucus hypersecretion, whe...
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Lung structure and function, Respiratory clinical practice Original Articles: Lung structure and function Source Type: research
Semin Thromb Hemost DOI: 10.1055/s-0039-1696942Since Virchow's autopsy studies in the mid-1800s, it has generally been believed that pulmonary embolism (PE) originated from the embolization of fibrin fragments from a deep venous thrombosis (DVT). However, a DVT is often not found in patients with PE (up to 50% of cases). Could fibrin form in the pulmonary vessels without coming from the periphery? In this review, the authors will try to support the hypothesis that a pulmonary thrombosis (PT) may develop. They will do so through different clinical models related to some pathological conditions such as pneumonia, chronic obs...
Source: Seminars in Thrombosis and Hemostasis - Category: Hematology Authors: Tags: Review Article Source Type: research
The first reusable, propellant-free inhaler is now available for patients with asthma and COPD, in line with NHS plans to reduce its carbon footprint and plastic waste.
Source: The Pharmaceutical Journal - Category: Drugs & Pharmacology Source Type: research
ConclusionControls need to be brought in to ensure that PM2.5 does not exceed a 50μg/m3 level due to the increase in disease incidence associated with same. The urban burning of solid fuels should be severely restricted.
Source: Age and Ageing - Category: Geriatrics Source Type: research
This study assessed the infective viral etiologies b...
Source: Respiratory Research - Category: Respiratory Medicine Authors: Tags: Research Source Type: research
Ozone exposure causes irritation, airway hyperreactivity (AHR), inflammation of the airways, and destruction of alveoli (emphysema), the gas exchange area of the lung in human and mice. This review focuses on the acute disruption of the respiratory epithelial barrier in mice. A single high dose ozone exposure (1 ppm for 1 h) causes first a break of the bronchiolar epithelium within 2 h with leak of serum proteins in the broncho-alveolar space, disruption of epithelial tight junctions and cell death, which is followed at 6 h by ROS activation, AHR, myeloid cell recruitment, and remodeling. High ROS levels activate a novel P...
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research
This study was designed to examine the association between sleep problems and different categories of OAD amongst US adults. METHODS: We conducted an observational, cross-sectional study using a nationally representative sample of the US civilian non-institutionalized population from 2007 to 2008 National Health and Nutritional Examination Survey (NHANES). A total of 3204 study participants aged ≥35 years were stratified into four groups, using a self-reported history of asthma and data from spirometry: asthma-COPD overlap (ACO) (n = 70, 2.2%), asthma (n = 168, 5.2%), chronic obstru...
Source: Sleep and Breathing - Category: Sleep Medicine Authors: Tags: Sleep Breath Source Type: research
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