Estimation of the α/β ratio of non-small cell lung cancer treated with stereotactic body radiotherapy

The radiobiological principles of stereotactic body radiation therapy (SBRT) are currently vividly discussed [1 –3]. Compared to conventional fractionation, SBRT may exhibit some unique biological features including beneficial effects such as enhancement of systemic anti-tumor immunity [4] and a better ability to kill cancer stem cells [5], but also a difficulty to overcome tumor hypoxia with one or only a few fractions due to limited reoxygenation [2,3]. More specifically, when cells in vitro are irradiated with doses comparably high to those used in SBRT, a deviation from the typical linear-quadratic shape of the cell survival curve beyond a certain threshold dose is observed, with a transition of t he continuously bending quadratic curve into a linear decline [3].

Source: Radiotherapy and Oncology - August 16, 2019 Category: Radiology Authors: Rainer J. Klement, Jan-Jakob Sonke, Michael Allg äuer, Nicolaus Andratschke, Steffen Appold, José Belderbos, Claus Belka, Karin Dieckmann, Hans T. Eich, Michael Flentje, Inga Grills, Michael Eble, Andrew Hope, Anca L. Grosu, Sabine Semrau, Reinhart A. S Tags: Original Article Source Type: research