A Laboratory brucella exposure in a uk hospital: a swiss cheese model?

Publication date: Available online 16 August 2019Source: Journal of Hospital InfectionAuthor(s): Fahima Begum, Charles Tilsed, Alastair McGregor, Gopal Rao
Source: Journal of Hospital Infection - Category: Infectious Diseases Source Type: research

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Authors: Maleki M, Salouti M, Shafiee Ardestani M, Talebzadeh A Abstract Brucellosis is one of the most common and important diseases between humans and animals. Herein, we developed a nanovaccine against Brucella melitensis based on oligopolysaccharide (OPS) antigen and PLGA nanoparticles. The conjugation of extracted OPS with poly lactic-co-glycolic acid was performed. The antigenicity evaluation was conducted in 4 groups of 5 female BALB/c mice including OPS-PLGA conjugate, OPS alone, PLGA alone and PBS as a control. The mice were vaccinated intra-peritoneal three times with two-week intervals. To determine the ...
Source: Artificial Cells, Nanomedicine and Biotechnology - Category: Biotechnology Tags: Artif Cells Nanomed Biotechnol Source Type: research
ConclusionGiven the presence of infection in rodents with tularemia agent in the studied area, it is crucial to elucidate the risks of rodent exposure to tularemia for physicians, health personnel and the general population.
Source: Comparative Immunology, Microbiology and Infectious Diseases - Category: Infectious Diseases Source Type: research
AbstractSheep brucellosis is a worldwide extended disease caused byB. melitensis andB. ovis, two species respectively carrying smooth or rough lipopolysaccharide. VaccineB. melitensis Rev1 is used againstB. melitensis andB. ovis but induces an anti-smooth-lipopolysaccharide response interfering withB. melitensis serodiagnosis, which precludes its use againstB. ovis whereB. melitensis is absent. In mice, Rev1 deleted inwbkC (Brucella lipopolysaccharide formyl-transferase) and carryingwbdR (E. coli acetyl-transferase) triggered antibodies that could be differentiated from those evoked by wild-type strains, was comparatively ...
Source: Veterinary Research - Category: Veterinary Research Source Type: research
AbstractA cross-sectional study was conducted to determine the seroprevalence ofBrucella spp. andLeptospira spp. and risk factors of exposure in cattle in three zones with varying land use types and wildlife –livestock interactions. Five villages were selected purposively; two in areas with intensive livestock–wildlife interactions (zone 1), another two in areas with moderate livestock–wildlife interactions (zone 2) and one in areas where wildlife–livestock interactions are rarer (zone 3). Sera samples were collected from 1170 cattle belonging to 390 herds in all the zones and tested for antibodies ...
Source: EcoHealth - Category: Environmental Health Source Type: research
Publication date: Available online 8 November 2019Source: Food Research InternationalAuthor(s): Maryam Dadar, Yadolah Fakhri, Youcef Shahali, Amin Mousavi KhaneghahAbstractBrucellosis is known as an influential zoonosis in different regions worldwide, with significant effects on the reproductive performance of livestock. Considering the high incidence of brucellosis in dairy products and further negative impacts on food safety, the present study was aimed to systematically investigate prevalence worldwide among published data regarding the identification of Brucella spp. in dairy products. In this ...
Source: Food Research International - Category: Food Science Source Type: research
Volume 47, Issue 1, December 2019, Page 4248-4256 .
Source: Artificial Cells, Blood Substitutes, and Biotechnology - Category: Biotechnology Authors: Source Type: research
AbstractToday, brucellosis is the most common global bacterial zoonosis, bringing with it a range of significant health and economic consequences, yet it is rarely identified from the archaeological record. Detection and understanding of past zoonoses could be improved by triangulating evidence and proxies generated through different approaches. The complex socio ‐ecological systems that support zoonoses involve humans, animals, and pathogens interacting within specific environmental and cultural contexts, and as such there is a diversity of potential datasets that can be targeted. To capture this, in this paper we consi...
Source: International Journal of Osteoarchaeology - Category: Science Authors: Tags: RESEARCH ARTICLE Source Type: research
AbstractMultilocus variable number tandem repeat analysis (MLVA) technique has wide applications in studying phylogenies and short-term epidemiology of pathogens. The technique has been extensively used worldwide in molecular epidemiology ofBrucella genus. Only one study on this aspect is reported from India despite its economic and public health significance in country. The present study isolatedB. abortus from domesticated bovines of Jammu region of Jammu and Kashmir state, India, and applied MLVA for 16 loci (MLVA-16). MLVA results were compared with the results of a previous study and with MLVA data of Indian isolates ...
Source: Tropical Animal Health and Production - Category: Veterinary Research Source Type: research
Publication date: January 2020Source: Microbial Pathogenesis, Volume 138Author(s): Chamith Hewawaduge, Amal Senevirathne, John Hwa LeeAbstractIn the present study, the importance of sodium bicarbonate antacid as an agent for an orally delivered attenuated Salmonella strain secreting Brucella antigens Cu–Zn superoxide dismutase (SodC) and outer membrane protein 19 (Omp19) as a live vaccine candidate against Brucella infection was investigated. First, Brucella antigens SodC and Omp19 were cloned into a prokaryotic constitutive expression vector, pJHL65. Then secretion of proteins was verified after transformation into ...
Source: Microbial Pathogenesis - Category: Infectious Diseases Source Type: research
This study presents the first evidence that the transcriptional regulator VjbR has important function in B. canis. In addition, according to its reduced virulence and the protective immunity it induces in mice, it can be a potential live attenuated vaccine against B. canis.
Source: Microbial Pathogenesis - Category: Infectious Diseases Source Type: research
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