Mitochondrial cell-free DNA secreted from porcine granulosa cells.

In conclusion, the proteasomal mitochondrial quality control system is upstream of mt-cfDNA secretion and autophagy plays a role in cellular digestion of mitochondrial DNA in the cytoplasm. It is further suggested that dsDNA is enclosed in certain vesicles or associated with small molecules and secreted into the medium.
PMID: 31411132 [PubMed - as supplied by publisher]

Source: Zygote - August 13, 2019 Category: Reproduction Medicine Authors: Kansaku K, Munakata Y, Shirasuna K, Kuwayama T, Iwata H Tags: Zygote Source Type: research