Decreased cathepsin V expression due to Fli1 deficiency contributes to the development of dermal fibrosis and proliferative vasculopathy in systemic sclerosis

Conclusion. Loss of CTSV expression may contribute to the development of fibrosis, vasculopathy and the altered phenotype of keratinocytes in SSc.

Source: Rheumatology - April 19, 2013 Category: Rheumatology Authors: Noda, S., Asano, Y., Takahashi, T., Akamata, K., Aozasa, N., Taniguchi, T., Ichimura, Y., Toyama, T., Sumida, H., Kuwano, Y., Yanaba, K., Tada, Y., Sugaya, M., Kadono, T., Sato, S. Tags: Systemic Sclerosis BASIC SCIENCE Source Type: research