Dynamic Enhancer DNA Methylation as Basis for Transcriptional and Cellular Heterogeneity of ESCs

Song et  al. used an allelic reporter approach to show super-enhancers allelic DNA methylation dynamics underlies locus-specific heterogeneity, which functionally impacts transcription and cellular states of mouse embryonic stem cells.

Source: Molecular Cell - August 14, 2019 Category: Cytology Authors: Yuelin Song, Patrick R. van den Berg, Styliani Markoulaki, Frank Soldner, Alessandra Dall ’Agnese, Jonathan E. Henninger, Jesse Drotar, Nicholas Rosenau, Malkiel A. Cohen, Richard A. Young, Stefan Semrau, Yonatan Stelzer, Rudolf Jaenisch Tags: Article Source Type: research