Rheumatoid arthritis: Maintaining ‘sufficient’ levels of this may help prevent the disease

RHEUMATOID arthritis affects around 400,000 Britons over the age of 16 in the UK. Although there is no cure for the condition, evidence suggests maintaining sufficient levels of a certain vitamin may help prevent the onset of the disease.
Source: Daily Express - Health - Category: Consumer Health News Source Type: news

Related Links:

This study investigates potential causes of the decreased disease activity by analysing fatty acid composition in erythrocytes and plasma phospholipids and serum metabolites in the participants of the MIRA trial. Twenty-three women completed the randomized 2 × 11-week cross-over dietary intervention, exchanging one cooked meal per day, five days a week, with a meal including 75 g blue mussels or 75 g meat. Fatty acid composition in erythrocytes and plasma and 1H-Nuclear Magnetic Resonance (1H-NMR) metabolomics data were analysed with multivariate data analysis. Orthogonal Projections to Latent Structures with Dis...
Source: Prostaglandins, Leukotrienes and Essential Fatty Acids (PLEFA) - Category: Lipidology Source Type: research
Abstract Multiple cytokines play a pivotal role in the pathogenesis of Rheumatoid Arthritis by inducing intracellular signaling and it is known that the members of the Janus kinase (JAK) family are essential for such signal transduction. Janus kinase 3 is a tyrosine kinase that belongs to the Janus family of kinases. Drugs targeting JAK3 in the treatment of Rheumatoid arthritis is relevant. Therefore, it is of interest to design suitable inhibitors for JAK3 dimer using molecular docking with Molegro Virtual Docker. The compound possessing the highest affinity score is subjected to virtual screening to retrieve inh...
Source: Bioinformation - Category: Bioinformatics Authors: Tags: Bioinformation Source Type: research
Publication date: Available online 22 August 2019Source: Journal of Clinical NeuroscienceAuthor(s): Bruno Kusznir Vitturi, Bruno Azeredo Coutinho Nascimento, Beatriz Rizkallah Alves, Felipe Sobolewski Carneiro de Campos, Dawton Yukito TorigoeAbstractBackgroundNeurological manifestations of Rheumatoid Arthritis (RA) are usually uncommon. However, a number of recent studies have reported that the burden of cognitive impairment in RA could be significant. We sought to explore the prevalence and clinical predictors of cognitive impairment in persons with RA.MethodsThis is a cross-sectional case-control study with patients with...
Source: Journal of Clinical Neuroscience - Category: Neuroscience Source Type: research
ConclusionsWhile many intervention regimens in other studies are administered prior to disease onset in animal models, the current study involves delivery of the potential therapeutic after disease onset. Based on the findings, vamorolone may offer an efficacious, yet safer alternative to conventional steroidal compounds in the treatment of rheumatoid arthritis and other inflammatory diseases.
Source: Inflammation Research - Category: Research Source Type: research
This study explored the role of central sensitization (CS) pain in patients with various rheumatic diseases using the CS inventory (CSI).MethodsA total of 193 patients of mean age 50.72  ± 9.65 years were included; they were divided into four different groups in terms of their rheumatic diseases. Patients with rheumatoid arthritis (RA), spondyloarthropathy (SpA), osteoarthritis (OA), and fibromyalgia syndrome (FMS) were evaluated in tertiary care rheumatology/pain medicine se ttings. Disease duration and activity, the Bath Ankylosing Spondylitis Disease Activity Index, the Disease Activity Score-2...
Source: Clinical Rheumatology - Category: Rheumatology Source Type: research
Negative associations between intake of omega-3 (n-3) long chain polyunsaturated fatty acids (LC PUFAs) and risk or risk factors of cardiovascular disease (CVD) and inflammation are generally seen [1-3]. Seafood, especially fatty fish, is the main dietary source of the bioactive n-3 LC PUFAs eicosapentaenoic acid (20:5n-3; EPA) and docosahexaenoic acid (22:6n-3; DHA). Fish as a source of n-3 LC PUFAs is not economically nor environmentally sustainable [4]. In contrast, blue mussel farming is beneficial for the environment since excessive nitrogen is removed at harvest and eutrophication of the sea is reduced [5].
Source: Prostaglandins, Leukotrienes and Essential Fatty Acids - Category: Biomedical Science Authors: Source Type: research
ConclusionThis systematic review and conventional meta-analysis demonstrated the overall similarity of the long-term efficacy and safety of biosimilar rituximab to those of originator rituximab in RA and NHL patients by combining direct evidence from head-to-head trials.PROSPERO registration No. CRD42019125138.
Source: BioDrugs - Category: Drugs & Pharmacology Source Type: research
Abstract OBJECTIVES: Evaluate the relationship between arthritis diagnosis in those over 50 and exposure to extreme air pollution in utero or infancy (
Source: Environmental Pollution - Category: Environmental Health Authors: Tags: Environ Pollut Source Type: research
Findings show a dose - or frequency - dependent association; all antibiotic classes linked to higher odds for RA
Source: Pulmonary Medicine News - Doctors Lounge - Category: Respiratory Medicine Tags: Family Medicine, Infections, Internal Medicine, Pharmacy, Pulmonology, Rheumatology, Journal, Source Type: news
ConclusionGEN inhibits IL-6–induced VEGF expression and angiogenesis partially through the JAK2/STAT3 pathway in RA, which has provided a novel insight into the antiangiogenic activity of GEN in RA.The translational potential of this articleOur study provides scientific guidance for the clinical translational research of GEN in the RA treatment.
Source: Journal of Orthopaedic Translation - Category: Orthopaedics Source Type: research
More News: Arthritis | Health | Rheumatoid Arthritis | Rheumatology | Vitamins