Changes In The Density Of Corneal Endothelial Cells In Elderly Diabetic Patients After Combined Phacovitrectomy And Ex-Press Glaucoma Implants.

Changes In The Density Of Corneal Endothelial Cells In Elderly Diabetic Patients After Combined Phacovitrectomy And Ex-Press Glaucoma Implants. Curr Pharm Biotechnol. 2019 Aug 08;: Authors: Lyssek-Boroń A, Krysik K, Kijonka M, Osuch M, Grabarek B, Dobrowolski D Abstract Corneal endothelial cells (ECD) are characterized by limited regenerative potential, which is additionally impaired in patients with diabetes. This retrospective study included 27 patients aged 58.1±13.6, 16 female and 11 males, who underwent 23-gauge vitrectomy in combination with cataract surgery (phacovitrectomy) and further Ex-PRESS shunt implantation throughout 2013-2017 at St. Barbara Hospital in Sosnowiec, Poland. In our study we distinguished 4 periods: initial period; after phacovitrectomy and removal of oil tamponade; and 3 and 12 months after implantation of the Ex-PRESS shunt. Statistical analysis was performed at the level of statistical significance of p < 0.05. It included analysis of variance (ANOVA) and Tukey's post-hoc test in order to determine the differences in the density of ECD cells/mm2 between the periods of observation. The paired samples t-Student test was also performed to determine whether the differences in visual acuity values before and after PPV and before and after Ex-PRESS shunt were statistically significant. The initial count of ECD cells was 2381.1±249, decreasing to 1872.8±350.7 cell/mm2 and finally to 1677.9±327 at the e...
Source: Current Pharmaceutical Biotechnology - Category: Biotechnology Authors: Tags: Curr Pharm Biotechnol Source Type: research