REV1-POL ζ Inhibition and Cancer Therapy

In a recent issue of Cell, Wojtaszek et  al. (2019) reported a small-molecule inhibitor of mutagenic translesion DNA synthesis, which targets the interaction between REV1 and REV7, sensitizes cancer cells to cisplatin in vitro and in vivo, and reduces mutagenesis.
Source: Molecular Cell - Category: Cytology Authors: Tags: Spotlight Source Type: research