TLRs in pulmonary diseases

Publication date: 15 September 2019Source: Life Sciences, Volume 233Author(s): Shweta Arora, Shaniya Ahmad, Rasha Irshad, Yamini Goyal, Sahar Rafat, Neha Siddiqui, Kapil Dev, Mohammad Husain, Shakir Ali, Anant Mohan, Mansoor Ali SyedAbstractToll-like receptors (TLRs) comprise a clan of proteins involved in identification and triggering a suitable response against pathogenic attacks. As lung is steadily exposed to multiple infectious agents, antigens and host-derived danger signals, the inhabiting stromal and myeloid cells of the lung express an aggregate of TLRs which perceive the endogenously derived damage-associated molecular patterns (DAMPs) along with pathogen associated molecular patterns (PAMPs) and trigger the TLR-associated signalling events involved in host defence. Thus, they form an imperative component of host defence activation in case of microbial infections as well as non-infectious pulmonary disorders such as interstitial lung disease, acute lung injury and airways disease, such as COPD and asthma. They also play an equally important role in lung cancer. Targeting the TLR signalling network would pave ways to the design of more reliable and effective vaccines against infectious agents and control deadly infections, desensitize allergens and reduce inflammation. Moreover, TLR agonists may act as adjuvants by increasing the efficiency of cancer vaccines, thereby contributing their role in treatment of lung cancer too. Overall, TLRs present a compelling and expe...
Source: Life Sciences - Category: Biology Source Type: research