Beijinchromes A-D, Novel Aromatic Compounds Isolated from Nocardia beijingensis NBRC 16342.

Beijinchromes A-D, Novel Aromatic Compounds Isolated from Nocardia beijingensis NBRC 16342. Chem Pharm Bull (Tokyo). 2019;67(8):775-777 Authors: Hoshino S, Awakawa T, Zhang H, Hayashi F, Abe I Abstract Nocardia is a potent bacterial producer of bioactive compounds. From a culture of Nocardia beijingensis NBRC 16342, we isolated four aromatic compounds, named beijinchromes A-D (1-4). We purified them by silica gel chromatography and reverse phase HPLC, and identified their structures by NMR and high resolution (HR)-MS analyses. 1, 2, and 4 are novel 1,2,3,8-tetrasubstituted naphthalenes, and 3 is a novel 3,8-disubstituted ortho-naphthoquinone. 1 and 2 exert antioxidant activities, and 3 exhibits antibiotic activity. Remarkably, the putative biosynthetic gene clusters for 1-4 are widely distributed in 37 Nocardia species, implying their potential to produce this family of compounds and important biological functions of beijinchromes. PMID: 31366826 [PubMed - in process]
Source: Chemical and Pharmaceutical Bulletin - Category: Drugs & Pharmacology Authors: Tags: Chem Pharm Bull (Tokyo) Source Type: research