Perivascular CD73+ cells attenuate inflammation and interstitial fibrosis in the kidney microenvironment.

In conclusion, CD73 in perivascular cells may act to suppress myofibroblast transformation and influence macrophages to promote a wound healing response. These results suggest that the purinergic signaling pathway in the kidney interstitial microenvironment orchestrates perivascular cells and macrophages to suppress inflammation and prevent progressive fibrosis.
PMID: 31364375 [PubMed - as supplied by publisher]

Source: Am J Physiol Renal P... - July 30, 2019 Category: Urology & Nephrology Authors: Perry HM, Gorldt N, Sung SJ, Huang L, Rudnicka KP, Encarnacion IM, Bajwa A, Tanaka S, Poudel N, Yao J, Rosin DL, Schrader J, Okusa MD Tags: Am J Physiol Renal Physiol Source Type: research