Pulmonary hypertension secondary to respiratory disease and/or hypoxia in dogs: Clinical features, diagnostic testing and survival

Publication date: Available online 30 July 2019Source: The Veterinary JournalAuthor(s): J.A. Jaffey, K. Wiggen, S.B. Leach, I. Masseau, R.E. Girens, C.R. ReineroAbstractPulmonary hypertension (PH) is associated with substantial morbidity and if untreated, mortality. The human classification of PH is based on pathological, hemodynamic characteristics, and therapeutic approaches. Despite being a leading cause of PH, little is known about dogs with respiratory disease and/or hypoxia (RD/H)-associated PH. Therefore, our objectives were to retrospectively describe clinical features, diagnostic evaluations, final diagnoses and identify prognostic variables in dogs with RD/H and PH.In 47 dogs identified with RD/H and PH, chronic airway obstructive disorders, bronchiectasis, bronchiolar disease, emphysema, pulmonary fibrosis, neoplasia and other parenchymal disorders were identified using thoracic radiography, computed tomography, fluoroscopy, tracheobronchoscopy, bronchoalveolar lavage, and histopathology. PH was diagnosed using transthoracic echocardiography. Overall median survival was 276.0 days (SE, 95% CI; 216, 0–699 days). Dogs with an estimated systolic pulmonary arterial pressure (sPAP) ≥47 mmHg (n = 21; 9 days; 95% CI, 0–85 days) had significantly shorter survival times than those <47 mmHg (n = 16; P = 0.001). Estimated sPAP at a cutoff of ≥47 mmHg was a fair predictor of non-survival with sensitivity of 0.78 (95% CI, 0.52-0.94) and specificity o...
Source: The Veterinary Journal - Category: Veterinary Research Source Type: research