Aberrant accumulation of Dickkopf 4 promotes tumor progression via forming the immune suppressive microenvironment in gastrointestinal stromal tumor

ConclusionsOur findings identified DKK4 as a proper tumor biomarker for prognosis predicting and recurrence monitoring, and suggested a novel immune ‐escape mechanism driving malignancy in GIST, which might be a potential therapeutic target to improve the effects of canonical RTK therapy and combined immunotherapy.

Source: Cancer Medicine - July 28, 2019 Category: Cancer & Oncology Authors: Ming Wang, Bo Ni, Chun Zhuang, Wen ‐Yi Zhao, Lin Tu, Xin‐Li Ma, Lin‐Xi Yang, Zhi‐Gang Zhang, Hui Cao Tags: ORIGINAL RESEARCH Source Type: research