Extracellular domain c-kit mutation with duplication of Ser501Ala502 found in gastrointestinal stromal tumors is more imatinib- and nilotinib-sensitive than that with duplication of Ala502Tyr503

Extracellular domain c-kit mutation with duplication of Ser501Ala502 found in gastrointestinal stromal tumors is more imatinib- and nilotinib-sensitive than that with duplication of Ala502Tyr503

Laboratory Investigation advance online publication, March 4 2013.
doi:10.1038/labinvest.2013.43

Authors: Ning-Ning Liu, Mizuka Ohkouchi, Yuka Hashikura, Noriko Kajimoto, Ikuo Matsuda, Koji Isozaki, Yasushi Toh, Tsuyoshi Takahashi, Toshirou Nishida
& Seiichi Hirota

Source: Laboratory Investigation AOP - March 4, 2013 Category: Laboratory Medicine Authors: Ning-Ning LiuMizuka OhkouchiYuka HashikuraNoriko KajimotoIkuo MatsudaKoji IsozakiYasushi TohTsuyoshi TakahashiToshirou NishidaSeiichi Hirota Tags: c-kit gene exon 9 gain-of-function mutation gastrointestinal stromal tumor imatinib nilotinib Source Type: research