Humanized yeast genetic interaction mapping predicts synthetic lethal interactions of FBXW7 in breast cancer

Synthetic lethal interactions (SLIs) that occur between gene pairs are exploited for cancer therapeutics. Studies in the model eukaryote yeast have identified ~  550,000 negative genetic interactions that have ...

Source: BMC Medical Genomics - July 27, 2019 Category: Genetics & Stem Cells Authors: Morgan W. B. Kirzinger, Frederick S. Vizeacoumar, Bjorn Haave, Cristina Gonzalez-Lopez, Keith Bonham, Anthony Kusalik and Franco J. Vizeacoumar Tags: Research article Source Type: research