Dynamic imaging of melanoma development in nude mice using high-frequency ultrasound and optical coherence tomography.

CONCLUSIONS: HFUS and OCT can monitor the dynamic development of cutaneous melanoma in nude mice, and their imaging performance differs in different stages of tumor development. PMID: 31340908 [PubMed - in process]
Source: Journal of Southern Medical University - Category: Universities & Medical Training Authors: Tags: Nan Fang Yi Ke Da Xue Xue Bao Source Type: research

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CONCLUSIONS: If further studies are needed to support its widespread clinical use, we believe that, in expert hands and with a interdisciplinary team, HFUS are already capable to reliably calculate a Breslow index in the large majority of patients with cutaneous melanoma. PMID: 31589132 [PubMed - as supplied by publisher]
Source: Current Radiopharmaceuticals - Category: Radiology Tags: Curr Radiopharm Source Type: research
In conclusion, our findings link the calcification of the vascular tissue with the expression of FGF23 in the vessels and with the elevation of circulating levels this hormone. Permanently Boosting Levels of Natural Killer Cells in Mice to Increase Cancer Resistance https://www.fightaging.org/archives/2019/09/permanently-boosting-levels-of-natural-killer-cells-in-mice-to-increase-cancer-resistance/ Researchers here demonstrate a very interesting approach to immunotherapy: they introduce engineered stem cells in mice that will give rise to additional natural killer T cells, boosting the capability of the ...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
Conditions:   Melanoma;   Breast Cancer;   Merkel Cell Carcinoma;   Squamous Cell Cancer;   Non Small Cell Lung Cancer;   Cervical Cancer;   Urothelial Carcinoma;   Ovarian Cancer;   Hepatocellular Carcinoma;   Small-cell Lung Cancer;   Microsatellite Instability High;   Gastric C ancer;   Esophageal Cancer Interventions:   Device: Echopulse;   Drug: Imiquimod;   Drug: Standard of Care PD-1 Therapy Sponsors:   C...
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
This is the case report of a male patient who presented with black pleural effusion that was later diagnosed as melanoma by medical thoracoscopy. This is the only case of melanoma diagnosed by medical thoracoscopy. Melanoma presenting with black pleural effusion is rare, with only five cases reported till date. In distinction to others, this is the only case where patient did not have a prior diagnosis of melanoma and was diagnosed by thoracoscopy. Reported is the case of a 49 ‐year‐old male who presented with dyspnoea and weight loss. Patient had a large left‐sided pleural effusion. Ultrasound showed thickened irreg...
Source: Respirology Case Reports - Category: Respiratory Medicine Authors: Tags: Case Report Source Type: research
Non-ablative pulsed focused ultrasound (pFUS) targets non-thermal forces that activate local molecular and cellular immune responses. Optimal parameters to stimulate immunotherapeutic tumor microenvironments (TME) and responses in different tumor types remain uninvestigated. Flank B16 murine melanoma and 4T1 breast tumors received 1 MHz pFUS at 1 –8 MPa peak negative pressures (PNP) and were analyzed 24 hr post-sonication. Necrosis or hemorrhage were unaltered in both tumors, but pFUS induced DNA strand breaks in tumor cells at PNP ≥6 MPa.
Source: Ultrasound in Medicine and Biology - Category: Radiology Authors: Tags: Original Contribution Source Type: research
CONCLUSION: The ultra-wide-field scanning laser ophthalmoscopy imaging characteristics of choroidal melanoma in the Optos® system do not significantly change after proton beam radiotherapy after a mean follow-up of 2 years. PMID: 31466473 [PubMed - as supplied by publisher]
Source: European Journal of Ophthalmology - Category: Opthalmology Authors: Tags: Eur J Ophthalmol Source Type: research
We present a patient with a CDKN2A germline mutation (p16-Leiden mutation) and mosaicism for neurofibromatosis type 2, who presented with a small asymptomatic pancreatic lesion, detected during endoscopic ultrasound screening of the pancreas. After resection, the lesion was found to be a well-differentiated pancreatic neuroendocrine tumor (PanNET). Molecular analysis of the tumor showed somatic loss of the second allele, supporting a causal relation of the PanNET to the underlying FAMMM syndrome. Recent data, showing the association between certain single-nucleotide polymorphisms in the CDKN2A gene and an increased inciden...
Source: The American Journal of Surgical Pathology - Category: Pathology Tags: Case Report Source Type: research
Authors: Lamagna B, Uccello V, Prisco F, Russo V, Lamagna F, Navas L, Mennonna G, Murino C, Meomartino L Abstract A 13-year-old Domestic Shorthair female cat, with a history of phthisis bulbi of the right eye, was referred for an acute increase in the size of the right ocular globe that occurred over a period of 1 month. Ocular examination revealed a large pink/greyish neoplastic mass involving the entire ocular surface. Ocular ultrasound and cytological examination confirmed intraocular tumor of the phthisical eye extending into the cranial space of the right orbit. The diagnosis of a primary, poorly pigmented iri...
Source: Veterinary Quarterly - Category: Veterinary Research Tags: Vet Q Source Type: research
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