The nightmare of calciphylaxis.

We report the rare case of a 53-year-old patient with the simultaneous presence of Fournier's gangrene and calciphylaxis, placing a special focus on diagnostic and therapeutic aspects. PMID: 31344746 [PubMed - as supplied by publisher]
Source: Aktuelle Urologie - Category: Urology & Nephrology Authors: Tags: Aktuelle Urol Source Type: research

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The patient visited Flinders Medical Centre, near Adelaide in Australia, for a routine appointment and doctors realised he had gangrene because of a condition which kills six out of 10 people who get it.
Source: the Mail online | Health - Category: Consumer Health News Source Type: news
In this study, we used an E. coli system for the efficient production of recombinant proteins and developed a bicistronic design (BCD) expression construct consisting of two copies of the C-terminal (247–370) domain of the alpha toxin (CPA-C) in the first cistron, followed by Cholera Toxin B (CTB) linked with another two copies of CPA-C in the second cistron that is controlled by a single promoter. Rabbits were immunized twice with purified proteins (rCPA-C rCTB-CPA-C) produced in the BCD expression system, with an inactivated recombinant E. coli vaccine (RE), C. perfringens formaldehyde-inactivated alpha toxoid (FA-...
Source: Protein Expression and Purification - Category: Biochemistry Source Type: research
We examined a patient aged 31 who had a sudden burning paraesthesia, pain and numbness in the lower legs together with an increased temperature of 39°C. Clinical examination showed asymmetrical sensory polyneuropathy more clearly seen in the lower legs and the left wrist, with high ESR (up to 44 mm/h), leukocytosis, slight anemia and proteinuria. CSF was normal. After three weeks the temperature suddenly increased again up to 39°C and severe flaccid distal tetraparesis was seen more clearly with foot drop in the left lower leg and dense oedema in the left wrist, purple cyanosis and haemorrhagic foci appeared on the...
Source: Acta Myologica - Category: Neurology Tags: Acta Myol Source Type: research
Conclusion: The profile of Limb amputation in Liberia is not very different from what is obtaining in the region. However the limitations of histology and other investigative procedure have affected the accurate diagnosis of certain conditions like tumours.
Source: Annals of African Medicine - Category: African Health Authors: Source Type: research
Two young and extremely talented rock and ice climbers set out to summit Mt. Washington, the highest peak in the Northeastern United States (6,288 feet) and considered to be the world’s most dangerous small mountain, in January of 1982. Despite...
Source: Medgadget - Category: Medical Devices Authors: Tags: Exclusive Rehab Source Type: blogs
Introduction: Critical limb threatening ischemia (CLTI) is the most severe form of peripheral arterial disease, characterized by chronic ischemic rest pain, ulcers, or gangrene, and carries a high risk of amputation. International consensus advocates revascularization therapy. However, patients with CLTI are often fragile elderly with significant comorbidities, while their vascular anatomy is not always suitable for open or endovascular revascularization. Recent studies have suggested fair outcomes of conservative treatment in some cases.
Source: European Journal of Vascular and Endovascular Surgery - Category: Surgery Authors: Source Type: research
Source: Infectious Diseases - Category: Infectious Diseases Authors: Source Type: research
Thromboangiitis obliterans, or Buerger disease, is a rare nonatherosclerotic segmental inflammatory vasculitis that generally affects young tobacco smokers. Although no surgical treatment is available, the most effective way to halt the disease's progress is smoking cessation. In this case report, a 29-year-old smoker showed up to emergency department with gangrene of his fifth left toe and extensive plantar ulceration. After investigative angiography, he was diagnosed with Buerger disease. On November 2017, he underwent fifth left toe amputation and hyperbaric therapy. Five months after amputation, the patient was rehospi...
Source: Advances in Skin and Wound Care - Category: Dermatology Tags: ONLINE EXCLUSIVE Source Type: research
ConclusionCecal volvulus should be kept in mind in a child presenting with signs suggestive of intestinal obstruction.
Source: International Journal of Surgery Case Reports - Category: Surgery Source Type: research
ConclusionsThe origin of the infection has a significant prognostic value in the mortality of the patient.ResumenObjetivoEvaluar el origen de la gangrena de Fournier (GF) como factor pronóstico de morbimortalidad.Material y métodosLos pacientes que acudieron a nuestra clínica con diagnóstico de GF entre 2010 y 2017 se incluyeron de forma retrospectiva. Los pacientes fueron categorizados según el origen de la infección. Se determinaron 3 factores de gravedad en cada grupo: duración de la estancia hospitalaria (días), índice de gravedad de GF y mortalidad. Se rea...
Source: Actas Urologicas Espanolas - Category: Urology & Nephrology Source Type: research
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