PRagMatic Pediatric Trial of Balanced versus nOrmaL Saline FlUid in Sepsis: the PRoMPT BOLUS Randomized Controlled Trial Pilot Feasibility Study

Resuscitation with crystalloid fluid is a cornerstone of pediatric septic shock treatment. However, the optimal type of crystalloid fluid is unknown. We aimed to determine the feasibility of conducting a pragmatic randomized trial to compare balanced (lactated Ringer ' s [LR]) with 0.9% normal saline (NS) fluid resuscitation in children with suspected septic shock. A pragmatic study design proved feasible to study comparative effectiveness of LR versus NS fluid resuscitation for pediatric septic shock.
Source: Current Awareness Service for Health (CASH) - Category: Consumer Health News Source Type: news