Comparison of the Diagnostic Ability of Endoscopic Ultrasonography and Abdominopelvic Computed Tomography in the Diagnosis of Gastric Subepithelial Tumors.

Conclusions: : APCT showed a lower overall accuracy than EUS; however, APCT remains a useful modality for malignant/potentially malignant gastric SETs. PMID: 31311912 [PubMed - as supplied by publisher]
Source: Clinical Endoscopy - Category: Gastroenterology Tags: Clin Endosc Source Type: research

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To identify significant clinical and CT features for the differentiation of gastrointestinal stromal tumors (GISTs) from leiomyomas in the esophagogastric junction (EGJ). One hundred thirty six patients with pathologically proven GISTs (nā€Š=ā€Š87) and leiomyomas (nā€Š=ā€Š49) in the EGJ were enrolled. And preoperative CT images were available in 73 GISTs cases and 34 leiomyoma cases. Two radiologists reviewed the CT images by consensus with regard to tumor size, shape, growth pattern, surface, enhancement pattern, enhancement degree, attention at each phasic image and the presence of surface ulcer, calcification, and intr...
Source: Medicine - Category: Internal Medicine Tags: Research Article: Observational Study Source Type: research
Publication date: Available online 11 December 2019Source: European Journal of RadiologyAuthor(s): Zeyang Chen, Jiejin Yang, Jiali Sun, Pengyuan WangAbstractPurposeThe purpose of this study was to investigate the computed tomography (CT) features of 2-5 cm gastric gastrointestinal stromal tumors (GISTs), schwannomas and leimyomas which have close relationship with malignancy evaluation and differential diagnosis.MethodSeventy-six patients with pathologically confirmed gastric submucosal tumors (SMTs) between 2-5 cm were included in this study, including 60 GISTs, 10 schwannomas and 6 leiomyomas. CT imaging fe...
Source: European Journal of Radiology - Category: Radiology Source Type: research
ConclusionsThis pilot study showed the potential of radiomics to distinguish GIST from other GI tumors, but no potential in predicting c-KIT mutational status and mitotic index of GISTs. Further optimization and validation of the radiomics model is required to incorporate radiomics in the diagnostic routine of GISTs.AcknowledgementM.J. Timbergen and M.P.A. Starmans contributed equally to this study.Legal entity responsible for the studyThe authors.FundingThe Netherlands Organization for Scientific Research.DisclosureAll authors have declared no conflicts of interest.
Source: Annals of Oncology - Category: Cancer & Oncology Source Type: research
ConclusionsAlthough a majority of the subepithelial lesions in the cardia of the stomach are benign, 20% of the cases diagnosed with GIST have a high malignant potential. Preoperative EUS-FNB might be a useful tool for decision-making regarding the ultimate management and outcomes of these lesions.
Source: Digestive Diseases and Sciences - Category: Gastroenterology Source Type: research
Esophageal submucosal tumors (SMTs) are tissue protuberances covered with normal mucosa, usually without clinical symptoms. In esophagus, leiomyomas and gastrointestinal stromal tumors (GISTs) are two common SMTs and originate from the muscularis propria (MP) layer. The most are benign, but 10.8% leiomyomas might turn into leiomyosarcomas. GISTs are reported to be potentially malignant, especially with the large size or irregular boundary. Submucosal tunneling endoscopic resection (STER) and endoscopic submucosal excavation (ESE) are recently introduced to remove submucosal tumors (SMTs) originating from the muscularis propria (MP) layer.
Source: Gastrointestinal Endoscopy - Category: Gastroenterology Authors: Tags: Tuesday abstract Source Type: research
Abstract The majority of the tumors in the gastrointestinal (GI) tract of rats and mice, with spindle cell morphology, are diagnosed as smooth muscle tumors (SMTs). Similarly, several decades ago human GI tumors with spindle cell morphology were also diagnosed as SMTs. However, later investigations identified most of these tumors in humans as gastrointestinal stromal tumors (GISTs). The GISTs are considered to arise from the interstitial cells of Cajal located throughout the GI tract. Positive immunohistochemical staining with CKIT antibody is a well-accepted diagnostic marker for GISTs in humans. Since there is a...
Source: Toxicologic Pathology - Category: Pathology Authors: Tags: Toxicol Pathol Source Type: research
ConclusionsThe scoring system based on the information of digital image analysis is useful in predicting GISTs in case of GMTs that are 2 –5 cm in size.
Source: Gastric Cancer - Category: Gastroenterology Source Type: research
Conclusions: CEH-EUS with perfusion analysis using perfusion analysis software could be a quantitative and independent method for predicting malignancy risk in gastrointestinal SETs. PMID: 30400724 [PubMed - as supplied by publisher]
Source: Gut and Liver - Category: Gastroenterology Tags: Gut Liver Source Type: research
Conclusion EUS-FNA/CNB is an effective modality for diagnosing UGI submucosal lesions. Awareness of potential errors due to sampling of the bowel wall, lesional cystic degeneration, as well as pancreatic heterotopia and Brunner gland hamartoma is essential in order to avoid false diagnoses.
Source: Journal of the American Society of Cytopathology - Category: Cytology Source Type: research
Conclusion EUS-FNA/CNB is an effective modality for diagnosing UGI submucosal lesions. Awareness of potential errors due to sampling of the bowel wall, lesional cystic degeneration, as well as pancreatic heterotopia, is essential in order to avoid false diagnoses.
Source: Journal of the American Society of Cytopathology - Category: Cytology Source Type: research
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