DNA damage accumulation during fractionated low-dose radiation compromises hippocampal neurogenesis

Radiotherapy is an effective treatment modality for patients of all ages with malignant and benign tumors. With intensity-modulated radiotherapy (IMRT) multiple photon-beams from different directions and with adjusted intensities permit close shaping of radiation dose to target volumes, thereby delivering high doses to tumors while sparing specific risk regions. However, with IMRT large volumes of non-targeted brain regions are exposed to daily low-dose radiation (LDR), which may adversely affect neurocognitive functions.
Source: Radiotherapy and Oncology - Category: Radiology Authors: Tags: Original Article Source Type: research