Side lying during nebulisation can significantly improve apical deposition in healthy adults and adults with mild cystic fibrosis lung disease: a randomised crossover trial

In people with and without Cystic Fibrosis (CF), does side lying during nebulisation change: the proportion of the dose loaded in the nebuliser that is deposited in the lungs; the uniformity of deposition thro...
Source: BMC Pulmonary Medicine - Category: Respiratory Medicine Authors: Tags: Research article Source Type: research

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Publication date: Available online 18 August 2019Source: Pulmonary Pharmacology &TherapeuticsAuthor(s): Michael R. Loebinger, Eva Polverino, Francesco Blasi, Stuart J. Elborn, James D. Chalmers, Harm AWM. Tiddens, Herman Goossens, Michael Tunney, Wenchun Zhou, Gerhild Angyalosi, Adam T. Hill, Charles S. Haworth, iBEST-1 Trial TeamAbstractIn patients with bronchiectasis (BE), infection with Pseudomonas aeruginosa (Pa) results in disease progression, frequent pulmonary exacerbations and lung function decline. However, at present, no inhaled antibiotics have been approved for the treatment of these patients. Tobramycin in...
Source: Pulmonary Pharmacology and Therapeutics - Category: Respiratory Medicine Source Type: research
Publication date: Available online 16 August 2019Source: The Lancet Respiratory MedicineAuthor(s): Brian O'Sullivan
Source: The Lancet Respiratory Medicine - Category: Respiratory Medicine Source Type: research
Publication date: Available online 16 August 2019Source: The Lancet Respiratory MedicineAuthor(s): Vikas Goyal, Keith Grimwood, Robert S Ware, Catherine A Byrnes, Peter S Morris, I Brent Masters, Gabrielle B McCallum, Michael J Binks, Heidi Smith-Vaughan, Kerry-Ann F O'Grady, Anita Champion, Helen M Buntain, André Schultz, Mark Chatfield, Paul J Torzillo, Anne B ChangSummaryBackgroundBronchiectasis guidelines recommend antibiotics for the treatment of acute respiratory exacerbations, but randomised placebo-controlled trials in children are lacking. We hypothesised that oral amoxicillin–clavulanate and azithrom...
Source: The Lancet Respiratory Medicine - Category: Respiratory Medicine Source Type: research
Abstract The test of sweat chloride is routinely performed as a worldwide newborn screening (NBS) to the diagnosis of cystic fibrosis (CF) in infants. However, the available methods for measurement of chloride in sweat suffer from such limitations as either low selectivity and/or requiring relatively large sample size. In this work, we have designed an analytical ruler that can measure chloride ion in sweat and hence can be used for the diagnosis of cystic fibrosis. This micro-pad (μ-PAD) device is fabricated by making hydrophilic micro-channel on a filter paper impregnated with silver dichromate. After additio...
Source: Analytica Chimica Acta - Category: Chemistry Authors: Tags: Anal Chim Acta Source Type: research
Conference abstracts
Source: The Aspergillus Website - updates - Category: Respiratory Medicine Authors: Source Type: news
Condition:   Cystic Fibrosis Interventions:   Drug: BI 1265162;   Drug: Placebo Sponsor:   Boehringer Ingelheim Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Condition:   Cystic Fibrosis Intervention:   Diagnostic Test: Sit to stand test Sponsor:   Boston Children’s Hospital Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Condition:   Cystic Fibrosis Interventions:   Drug: ELX/TEZ/IVA;   Drug: IVA;   Drug: TEZ/IVA Sponsor:   Vertex Pharmaceuticals Incorporated Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Condition:   Cystic Fibrosis Interventions:   Drug: ELX/TEZ/IVA;   Drug: IVA Sponsor:   Vertex Pharmaceuticals Incorporated Available
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Condition:   Cystic Fibrosis Intervention:   Diagnostic Test: Sit to stand test Sponsor:   Boston Children’s Hospital Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
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