Increased Pulmonary GM-CSF Causes Alveolar Macrophage Accumulation: Mechanistic Implications for Desquamative Interstitial Pneumonitis.

CONCLUSIONS: In mice, cigarette-smoke increased pulmonary GM-CSF and AM proliferation, chronically increased pulmonary GM-CSF recapitulated the cardinal features of DIP, including AM accumulation, emphysema, secondary polycythemia, and increased mortality. Results suggest pulmonary GM-CSF may be involved in the pathogenesis of DIP.
PMID: 31310562 [PubMed - as supplied by publisher]

Source: Am J Respir Cell Mol... - July 15, 2019 Category: Respiratory Medicine Authors: Suzuki T, McCarthy C, Carey B, Borchers M, Beck D, Wikenheiser-Brokamp KA, Black D, Chalk C, Trapnell BC Tags: Am J Respir Cell Mol Biol Source Type: research