Detection of Crohn ’s disease with diffusion images versus contrast-enhanced images in pediatric using MR enterography with histopathological correlation

AbstractThe purpose of this study was to determine whether MRE performed with diffusion-weighted imaging (DWI) sequences is comparable to contrast-enhanced MRE in the detection of active small-bowel inflammation in pediatric patients with Crohn ’s disease (CD). We included in our study 68 patients with diagnosis of CD between April 2015 and June 2018 that underwent MRE examination. Examination protocol includes coronal and axial FISP, T2-w half-Fourier RARE and DWI sequences, a baseline coronal T1-w fat-saturated ultrafast (GRE) sequence followed by contrast 3D T1-w GRE. All images were assessed by two radiologists who graded each of bowel segments for the presence of inflammation on a four-point confidence scale on the basis of wall thickening and wall signal on DWI and ADC maps and comparing their results with post-contrast image s. When considering all bowel segments, we found 41 true positive and 25 true negative on DWI. One false positive case corresponded to the absence of inflammatory histopathology changes at the level of the terminal ileum in a 15-year-old male, and one false negative case was in a 10-year-old female with only jejunal lesion. The corresponding sensitivity, specificity, PPV, NPV and accuracy were 97.6% (95% CI 67.7–99.7), 96.1% (95% CI 66.7–98.5), 97.6% (95% CI 70.8–98.4), 96.1% (95% CI 64.2–90.6) and 97% (95% CI 84.2–97.5), respectively. Analyzing the gadolinium-enhanced set, 35 true p ositive and 25 true negative ...
Source: La Radiologia Medica - Category: Radiology Source Type: research

Related Links:

This study aimed to understand the disease characteristics and treatment outcomes of Crohn ’s disease (CD) in a real-world setting in China.
Source: BMC Gastroenterology - Category: Gastroenterology Authors: Tags: Research article Source Type: research
Journal of Laparoendoscopic&Advanced Surgical Techniques, Ahead of Print.
Source: Journal of Laparoendoscopic and Advanced Surgical Techniques - Category: Surgery Authors: Source Type: research
Authors: Wu CQ, Lin QR, Ying SJ, Luo JK, Hong WJ, Lin ZJ, Jiang Y Abstract Aims The aryl hydrocarbon receptor (AhR) plays a pivotal role in regulating the innate and the acquired immune systems. The present study aimed to investigate the association of Crohn's disease (CD) with AhR polymorphisms in a cohort of patients from Southeast China. Methods An improved multiple ligase detection reaction technique was applied to examine the polymorphisms of rs2158041, rs2066853, and rs10249788 in 310 patients with CD and 573 controls. Results Compared to the controls, the variant allele (T) and genotype (CT+TT) of rs2158041 ...
Source: Immunological Investigations - Category: Allergy & Immunology Tags: Immunol Invest Source Type: research
Authors: Seyedian SS, Nokhostin F, Malamir MD Abstract Ulcerative colitis (UC) and Crohn's disease (CD) are classified as chronic inflammatory bowel diseases (IBD) which have similar symptoms and lead to digestive disorders and inflammation in the digestive system. The reason why they occur is still a mystery. A number of factors can be attributed to the prevalence of CD and UC, some of which include geographical location, inappropriate diet, genetics, and inappropriate immune response. Both diseases are more often diagnosed in urban areas compared to rural areas and both have their own challenges and side effects,...
Source: Journal of Medicine and Life - Category: General Medicine Tags: J Med Life Source Type: research
This study aimed to evaluate and compare the prognostic value of the above features in a Japanese (n=283) and a Scottish (n=163) cohort, as well as to compare 2 different reporting methodologies: analyzing each feature from across every tissue slide from the whole tumor and a more efficient methodology reporting each feature from a single slide containing the deepest tumor invasion. In the Japanese cohort, there was an excellent agreement between the multi-slide and single-slide methodologies for TB, PDC, and DR (κ=0.798 to 0.898) and a good agreement when assessing Crohn-like lymphoid reaction (κ=0.616). TB (h...
Source: The American Journal of Surgical Pathology - Category: Pathology Tags: Original Articles Source Type: research
Source: Clinical Nutrition - Category: Nutrition Authors: Tags: Nutrition and chronic disease/Vitamins, antioxidants and minerals Source Type: research
Source: Clinical Nutrition - Category: Nutrition Authors: Tags: Perioperative care I Source Type: research
Source: Clinical Nutrition - Category: Nutrition Authors: Tags: Nutritional assessment I Source Type: research
Source: Clinical Nutrition - Category: Nutrition Authors: Tags: Liver and gastrointestinal tract I Source Type: research
Source: Clinical Nutrition - Category: Nutrition Authors: Tags: Liver and gastrointestinal tract I Source Type: research
More News: Crohn's Disease | Pediatrics | Radiology | Study