Tumor Organoids Hold Promise for Personalizing Cancer Therapy

The three-dimensional cell cultures are still in the development phase, but researchers are excited about their use to predict patients' responses to various treatment options.
Source: The Scientist - Category: Science Tags: Notebook Magazine Issue Source Type: news

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New J. Chem., 2019, Advance Article DOI: 10.1039/C9NJ03088C, PaperHaiyao Yang, Yanxian Guo, Zhengfei Zhuang, Huiqing Zhong, Chaofan Hu, Zhiming Liu, Zhouyi Guo MoO3 −x is synthesizedvia a one-pot hydrothermal method, with excellent stability against aging, heat, laser exposure and chemical etching. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - New J. Chem. latest articles - Category: Chemistry Authors: Source Type: research
Abstract PURPOSE: To evaluate the use of individualized piano instruction (IPI) for improving cognition among breast cancer survivors. PARTICIPANTS & SETTING: Six participants were included in an eight-week piano program with three data collection time points at baseline, midpoint, and postintervention. Participants were recruited from the breast cancer clinic of a university cancer center in South Florida. METHODOLOGIC APPROACH: Neurocognitive, psychosocial, and self-report assessments were conducted to determine potential benefits and program feasibility, including the NIH Toolbox® Cognition Ba...
Source: Oncology Nursing Forum - Category: Nursing Authors: Tags: Oncol Nurs Forum Source Type: research
Conclusion: Glo-I is positively correlated with HCC proliferation. Inhibition of Glo-I reduced proliferation, migration and colony formation. In turn, sorafenib increases Glo-I. Co-treatment using Glo-I inhibitors could enhance susceptibility of HCC to sorafenib.
Source: Frontiers in Oncology - Category: Cancer & Oncology Source Type: research
Publication date: December 2019Source: Materials Science and Engineering: C, Volume 105Author(s): Mohammad Ansari, Ashkan Bigham, Hossein Abbastabar AhangarAbstractSpinel ferrite-based nanoparticles are being widely applied in bone tissue regeneration because of their outstanding properties such as their capability to be applied in hyperthermia-based bone cancer therapy. In the present study, Cu0.3Zn0.2Mg0.5Fe2O4 nanoparticles are synthesized through thermal-treatment method followed by calcination at 650 °C. The calcined nanoparticles are characterized through X-ray diffraction (XRD), field-emission scanning electro...
Source: Materials Science and Engineering: C - Category: Materials Science Source Type: research
Publication date: December 2019Source: Materials Science and Engineering: C, Volume 105Author(s): Buddolla Anantha Lakshmi, Sanghyo KimAbstractNanostructured metal-organic frameworks (N-MOFs) are crystalline coordination nanopolymers in which metals are conjugated with organic and inorganic linker molecules. At present, N-MOFs have attracted significant interest owing to their intrinsically high porosity and ultrahigh surface areas, which allow them to be loaded with a broad array of materials, including drug molecules. In addition, N-MOFs possess other unique properties, such as good mobility, high reactivity, outstanding...
Source: Materials Science and Engineering: C - Category: Materials Science Source Type: research
Publication date: Available online 17 August 2019Source: Chinese Chemical LettersAuthor(s): Shuai Wang, Dandan Shen, Lijie Zhao, Xiaohan Yuan, Jialing Cheng, Bin Yu, Yichao Zheng, Hongmin LiuAbstractTargeting bromodomain-containing protein 4 (BRD4) has been proved to be an effective strategy for cancer therapy. To date, numerous BRD4 inhibitors and degraders have been identified, some of which have advanced into clinical trials. In this work, a focused library of new [1,2,4]triazolo[1,5-a]pyrimidine derivatives were discovered to be able to inhibit BRD4. WS-722 inactivated BRD4 (BD1/BD2), BRD2 (BD1/BD2) and BRD3 (BD1/BD2) ...
Source: Chinese Chemical Letters - Category: Chemistry Source Type: research
Immunotherapy, Ahead of Print.
Source: Immunotherapy - Category: Allergy & Immunology Authors: Source Type: research
In conclusion, our data show how oncogenic and tumor-suppressive drivers of cellular senescence act to regulate surveillance processes that can be circumvented to enable SnCs to elude immune recognition but can be reversed by cell surface-targeted interventions to purge the SnCs that persist in vitro and in patients. Since eliminating SnCs can prevent tumor progression, delay the onset of degenerative diseases, and restore fitness; since NKG2D-Ls are not widely expressed in healthy human tissues and NKG2D-L shedding is an evasion mechanism also employed by tumor cells; and since increasing numbers of B cells express NKG2D ...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
Authors: Abdellatif AAH Abstract Numerous normal and tumors cells are well-known to express the somatostatin receptors (SSTRs) on their surface which make the receptor be useful for tumor scintigraphy. Thus, identification of SSTRs is beneficial, especially SSTR2. The somatostatin analogue, Octreotide (OCT) was chosen as a ligand, as it is known to selectively bind to SSTR2. Moreover, polyethylene glycol (PEG), 8armPEG was used as a branched PEG to provide a low non-specific cell binding and easily chemical modification. OCT, and fluorescein (Flu) were conjugated to branched PEG using a water-soluble carbodiimide (...
Source: Drug Development and Industrial Pharmacy - Category: Drugs & Pharmacology Tags: Drug Dev Ind Pharm Source Type: research
Publication date: Available online 17 August 2019Source: Seminars in Cancer BiologyAuthor(s): Jan Budczies, Klaus Kluck, Wolfgang Walther, Ulrike SteinAbstractMetastasis remains the key issue impacting cancer patient survival and failure or success of cancer therapies. Metastatic spread is a complex process including dissemination of single cells or collective cell migration, penetration of the blood or lymphatic vessels and seeding at a distant organ site. Hundreds of genes involved in metastasis have been identified in studies across numerous cancer types. Here, we analyzed how the metastasis-associated gene MACC1 cooper...
Source: Seminars in Cancer Biology - Category: Cancer & Oncology Source Type: research
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