3D printed mold-based capsaicin candy for the treatment of oral ulcer

Publication date: Available online 12 July 2019Source: International Journal of PharmaceuticsAuthor(s): Heliu Jiang, Xiang Yu, Rongzhen Fang, Zhimei Xiao, Yiguang JinAbstractOral ulcer is one common mucosal disease with high prevalence. Here, capsaicin candies were prepared based on stereolithographically (SLA) 3D printed molds. The molds can be freely designed depending on the needs of patients, involving symmetric shapes (e.g., round, four-lead clover and cube), asymmetric shapes (e.g., car) and various color (e.g., blue, red and yellow). A two-part-combined mold was poured with the xylitol-based material and separated to obtain hard candies. Capsaicin was amorphous in candies according to the differential scanning calorimetry and X-ray diffraction. Poloxamer 188 improved the release of capsaicin from the candies. Rat oral ulcer models were established on the tongue with phenol liquids. The blank candy, 0.05% capsaicin candy and dexamethasone were respectively administered on the ulcer once daily. On Day 7, a healing rate of 97.8% was achieved by the capsaicin candy, much higher than those in the other groups. Moreover, the blank candy also showed the remarkable ulcer healing effect due to the presence of xylitol and poloxamer. Capsaicin remarkably enhanced the reepithelialization of ulcer tissues and showed strong anti-inflammatory effect by reducing the expressions of THF-α and IL-6. 3D printing-based capsaicin candies provide an interesting therapeutic choice for the pe...
Source: International Journal of Pharmaceutics - Category: Drugs & Pharmacology Source Type: research