Stabilization of Sir3 interactions by an epigenetic metabolic small molecule, O-acetyl-ADP-ribose, on yeast SIR-nucleosome silent heterochromatin.

In conclusion, our results reveal the importance of AAR, indicating that it not only affects the conformational rearrangement of SIR complexes but also might function as a critical fine-tuning modulatory component of yeast silent SIR-nucleosome pre-heterochromatin by stabilizing the intermolecular interaction between Sir3 N- and C-terminal regions.
PMID: 31295433 [PubMed - as supplied by publisher]

Source: Archives of Biochemistry and Biophysics - July 7, 2019 Category: Biochemistry Authors: Wang SH, Lee SP, Tung SY, Tsai SP, Tsai HC, Shen HH, Hong JY, Su KC, Chen FJ, Liu BH, Wu YY, Hsiao SP, Tsai MS, Liou GG Tags: Arch Biochem Biophys Source Type: research