RNA Synthesis and Capping by Non-segmented Negative Strand RNA Viral Polymerases: Lessons From a Prototypic Virus

This article reviews what has been learned from biochemical and structural studies on the VSV RNA biosynthesis machinery, and then focuses on recent advances in our understanding of regulatory and catalytic roles of the PRNTase domain in RNA synthesis and capping.
Source: Frontiers in Microbiology - Category: Microbiology Source Type: research

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The World Health Organization's emergencies chief said the ongoing Ebola outbreak in Congo is approaching a "stark" milestone with nearly 2,000 people killed by the virus in the year-long epidemic
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The U.S. Department of Health and Human Services (HHS) said on Wednesday it will fund the manufacturing of Merck&Co Inc's investigational Ebola vaccine called V920, in response to the outbreak of the deadly virus in the Democratic Republic of the Congo (DRC).Reuters Health Information
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[WHO] Kasese, 22nd August 2019:- The United Kingdom (UK) through its Department for International Development (DFID) has provided eight million pounds to assist countries bordering the Democratic Republic of Congo (DRC) to prevent Ebola Virus Disease (EVD) from crossing borders in the region.
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AbstractEfficient viral vectors for mapping and manipulating long-projection neuronal circuits are crucial in structural and functional studies of the brain. The SAD strain rabies virus with the glycoprotein gene deleted pseudotyped with the N2C glycoprotein (SAD-RV( ΔG)-N2C(G)) shows strong neuro-tropism in cell culture, but itsin vivo efficiency for retrograde gene transduction and neuro-tropism have not been systematically characterized. We compared these features in different mouse brain regions for SAD-RV-N2C(G) and two other widely-used retrograde tracers, SAD-RV( ΔG)-B19(G) and rAAV2-retro. We found that...
Source: Neuroscience Bulletin - Category: Neuroscience Source Type: research
Disasters both natural and anthropogenic are increasing in intensity and frequency. 2018 marked the eighth consecutive year in which greater than seven high-consequence natural disasters occurred in the United States alone. These numbers do not include mass shootings or disease outbreaks, such as measles, influenza, and hepatitis A.
Source: Critical Care Clinics - Category: Intensive Care Authors: Tags: Preface Source Type: research
Outbreaks of Ebola virus disease and high-risk transmissible infections are increasing and pose threats to health care workers and global health systems. Previous outbreaks offer lessons for health system preparedness and response, including establishment of hospital-based high-risk pathogen treatment units. Their creation demands early preparation and interprofessional coordination; infection prevention and control; case management training; prepositioning of supplies; conversion of existing structures to treatment units; and strengthening communication and research platforms. Hospital-based Ebola and high-risk pathogen t...
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